Reaction state_transition re337 map

JNK*@Cytosol map → JNK*|​pho|​active@Cytosol map

Reaction regulators:
Catalysis
  1. TNF:​TNFR2*:​TRAF1:​TRAF2@Membrane map
  2. FADD:​RIPK1|​ubi:​TNF:​TNFR1*:​TRADD:​TRAF2|​ubi@Membrane map
Unknown_catalysis
  1. CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@Membrane map
Unknown_inhibition
  1. IFNG|​hm2@default map





Identifiers

Maps_Modules

References
PMID:16713974
TLR2 activates (induces phosphorylation of) ERKs, JNKs, and p38 rapidly and transiently in control macrophages.
This activation is inhibited by IFNG signaling.
PMID:11438547, PMID:24378531
Both TNFR1 and TNFR2 signaling pathways induce JNK activation and downstrean c-jun phosphorylation.