Reaction transcription re21 map

gIL10@Cytosol map → rIL10@Cytosol map

Reaction regulators:
Catalysis
  1. BCL3@Cytosol map
  2. FOS@Cytosol map
  3. TGFB1@default map
  4. CSF1:​CSF1R@Membrane map
  5. CD14:​IRAK2:​IRAK4:​LY96:​MYD88:​TIRAP:​TLR2/4*@Membrane map
  6. CREB1|​pho|​active@Cytosol map
  7. AP1*@Cytosol map
  8. JUN|​pho|​active@Cytosol map
  9. MAF@Cytosol map
Inhibition
  1. IRF5@Cytosol map
Unknown_catalysis
  1. IFNG|​hm2@default map





Identifiers

Maps_Modules

References
PMID:20547845
TLR4 signaling downstream of HMGB1 induces secretion of IL10
PMID:16713974
RNAi-mediated knockdown of CREB, Fos, and Jun expression resulted in diminished TLR2-induced IL-10 production
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
AP1.
PMID:17404308
CSF1 upregulates expression of IL10 and CCL2 probably via CSF1R.
PMID:15749884
c-Maf binds to the ???206/???171 region in the IL-10 promoter and upregulates IL10 expression.