Catalysis

1. p110*:​p85*@Cytosol

Inhibition

1. IFNG|​hm2@default

Identifiers

Maps_Modules

References
PMID:11687500
PI3K converts phosphatidylinositol 4,5-biphosphate ( PI(4,5)P 2 ) to phosphatidylinositol 3,4,5-triphosphate ( PI(3,4,5)P 3 ), which is secondary messenger involved the in regulation of various process .
PI(3,4,5)P 3 associates with the inner lipid bilayer of the plasma membrane and promotesthe recruitment of proteins with pleckstrin homology (PH) domains such as AKT and PDK. Upon binding to the membrane AKT and PDK became active.
Notably, translocation of AKT to the plasma membrane also facilitates its phosphorylation by PDK.
PMID:16713974
TLR signaling activates and IFNG inhibits PI3K pathway