Protein TGFB1 map

Identifiers
HUGO:TGFB1

Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
PMID:22703233
TGFB1 participates in M2 activation.
PMID:7594497
TGFB1 upregulates IL10 expression in macrophages.
TGFB1 and IL10 dowregulate expression of TNF.
PMID:21278795
TGFB-induced IRAK3 (IRAK-M) expression in tumor-associated macrophages
and inhibit TLR-dependent signaling
PMID:20644162
Cytokine-induced CD33+ human MDSCs have upregulated iNOS, TGF??, VEGF.
PMID:19109155
MDSC inhibit cytotoxicity, NKG2D expression, and IFN-gamma production of NK cells both in vitro and in vivo.
Membrane-bound TGF-beta1 on MDSC is responsible for MDSC-mediated suppression of NK cells.

TGFB1@Cytosol

Identifiers

Maps_Modules

References

TGFB1@default

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. TGFB1@Cytosol map
In compartment: default
  1. TGFB1@default map
Participates in complexes:
In compartment: Membrane
  1. TGFB1:​TGFBR1:​TGFBR2@Membrane map
Participates in reactions:
As Reactant or Product:
  1. rTGFB1@Cytosol map → map TGFB1@Cytosol map
  2. TGFB1@Cytosol map → map TGFB1@default map
  3. TGFB1@default map + TGFBR1@Membrane map + TGFBR2@Membrane map → map TGFB1:​TGFBR1:​TGFBR2@Membrane map
As Catalyser:
  1. gTNF@Cytosol map → map rTNF@Cytosol map
  2. gIL10@Cytosol map → map rIL10@Cytosol map
  3. gIRAK3@Cytosol map → map rIRAK3@Cytosol map
  4. SMAD3@Cytosol map → map SMAD3|​pho@Cytosol map
  5. SMAD2@Cytosol map → map SMAD2|​pho@Cytosol map