Protein LGALS3 map

Identifiers
HUGO:LGALS3

Maps_Modules
MODULE:MACROPHAGE
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS

References
PMID:22703233
TGFBR2 upregulates expression of markers M2 activation as ARG1, MCR2 and LGALS3 (galecsin3) and induces AKT activation.
PMID:18250477
LGALS3 participates in M2 activation of macrophages. And vice versa classically activated macrophages down-regulate galectin-3 expression and show reduced galectin-3 expression on the cell surface.
IL-4 or IL-13 stimulated the release of galectin-3
into the culture media in both BMDMs and PBMs.
An IL-4-mediated LGALS3 (galectin-3) autocrine loop promotes alternative macrophage activation and is blocked by pharmacological inhibition of galectin-3 and its receptor CD98.

LGALS3@default

Identifiers

Maps_Modules

References

LGALS3@Cytosol

Identifiers

Maps_Modules

References

Modifications:
In compartment: Cytosol
  1. LGALS3@Cytosol map
In compartment: default
  1. LGALS3@default map
Participates in complexes:
In compartment: Membrane
  1. LGALS3:​SLC3A2@Membrane map
Participates in reactions:
As Reactant or Product:
  1. rLGALS3@Cytosol map → map LGALS3@Cytosol map
  2. LGALS3@Cytosol map → map LGALS3@default map
  3. LGALS3@default map + SLC3A2@Membrane map → map LGALS3:​SLC3A2@Membrane map
  4. LGALS3@Cytosol map → map M2 phenotype of macrophages_or_MDSC@Membrane map
As Catalyser:
  1. p85*@Cytosol map → map p85*@Cytosol map