Phenotype NF-_kappa_B pathway map
NF-_kappa_B pathway@Cytosol

References
em_re1550( EMT Senescence  map ):
PMID:8867670
PMID:12379770
PMID:11035067
PMID:2065663
PMID:8603703
PMID:11788351
PMID:8797825
ROS induces NF_kappa_B pathway activation
em_re1551( EMT Senescence  map ):
PMID:27713146
Classical NF-??B activation depends on the I??B?? phosphorylation and degradation induced by the activation of kinases, such as I??B?? kinase and TAK1
em_re1561( EMT Senescence  map ):
PMID:21667018
PMID:16001073
Rac1B is an alternatively spliced form of Rac1 gene.
Rac1B does not lead to lamellipodia formation, or the activation of PAK1, AKT1, or c-Jun-NH2- kinase activities.
However, Rac1B retains the ability to stimulate the NF-kappa-B pathway.
em_emtc_emtc_re6( EMT Senescence  map ):
PMID:21883379
PMID:18297062
TWIST is a downstream target of HIF-1
Hypoxia or HIF-1 induces EMT through the direct activation of TWIST expression
PMID:19412634
Twist is a target of Snail1
PMID:22945800
PMID:21317430
Expression of Twist1 and Snail1 are mutually dependent
Knock-down of Snail1 downregulates Twist1 protein and mRNA
Knock- down of Twist1 interferes with TGFb-mediated induction of Snail1.
PMID:22006115
Alternatively, it has also been reported that Snail1 transcriptionally represses Twist1
PMID:16831886
PMID:18832382
HMGA2 directly binds to the SNAIL1 promoter and acts as a transcriptional regulator of SNAIL1 expression.
HMGA2 cooperates with SMAD3 and SMAD4 to execute a dramatic super-induction of the SNAIL1 promoter.
Same results were obtained with SNAI2, ZEB1, ZEB2 and TWIST1
HMGA2 cooperates with TGFB1 signaling to represse ID2 transcriptomal expression
PMID:17403902
Twist1 is a direct downstream target of NKFB.
em_emtc_emtc_re8( EMT Senescence  map ):
RAC1B increases the cellular level of ROS, causing an upregulation of Snail rexpression and induction of EMT
PMID:17563753
Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition.
em_emtc_emtc_re22( EMT Senescence  map ):
PMID:10048576
The gene expressions of MMP-1, MMP-3, and MMP-9 and gelatinolytic activity of MMP-9 were significantly increased in high ETS-1 expression cells.
Low ETS-1 expression cells could not spread on a vitronectin substratum, and the phosphorylation of focal adhesion kinase was markedly impaired because of the reduced expression of integrin b3
PMID:19208835
TCF8 (ZEB1) regulates cell invasion and migration via MMP1 expression.
TCF8 is likely to be dispensable for endothelial cell motility.
One possible mechanism underlying the increased invasiveness and migration might be the up-regulated digestion of ECMs via TCF8-mediated transcriptional regulation of the gene encoding MMP1.
MMP1 induction during tube formation was significantly enhanced in Matrigel when TCF8 was silenced
PMID:21081489
MiR-200b Regulates Ets-1-associated Genes
Suppression of endogenous miR-200b induced MMP-1 and VEGFR2 expressions
Overexpression of Ets-1 did not completely reverse miR- 200b-associated MMP-1 and VEGFR2 down-regulation.
It indicates that miR-200b, apart from targeting Ets-1, might silence other target proteins involved in transcription of the indicated genes.
PMID:20589835
Our results indicate that MT1-MMP is a direct down-stream target in the Wnt signaling pathway, and that one of the ways accumulated beta-catenin contributes to colorectal carcinogenesis is by transactivating this gene.
MT1-MMP is one target gene of Lef-1/Tcf-4 (Takahashi et al, 2002)
PMID:22439866
c-Myb strongly increased the expression/activity of cathepsin D and matrix metalloproteinase (MMP) 9 and significantly downregulated MMP1.
PMID:9811054
Nuclear factor kappaB/p50 activates an element in the distal matrix metalloproteinase 1 promoter in interleukin-1beta-stimulated synovial fibroblasts.
PMID:16556862
ROS regulate MMP gene expression and activation of proenzymes. MMP-1, MMP-2, MMP-7, and MMP-9 are activated by ROS through interactions with thiol groups
em_emtc_emtc_re55( EMT Senescence  map ):
PMID:13130303
PMID:18403754
PMID:16607286
Keratin-14, 18, 19, Vimentin are putative direct HIF1 target genes
http://www.omicsonline.org/1948-5956/JCST-03-035.php
Genes induced by HIF-1 in cancer cells include KRT-14, 18, 19, Vimentin:
PMID:16077980
the NF-kappaB binding site is located in the human vimentin promoter.
em_emtc_emtc_re63( EMT Senescence  map ):
PMID:15003528
NF-kappaB binds to a polymorphic repressor element in the MMP-3 promoter.
em_emtc_emtc_re65( EMT Senescence  map ):
PMID:16079281
MMP-9 transcription is activated in response to Snail expression
Oncogenic H-Ras (RasV12) synergistically co-operates with Snail in the induction of MMP-9 transcription and expression.
Phosphorylated Sp-1 is recruited to the MMP-9 promoter following activation of the Erk1/2 pathway
PMID:19564415
The transcription factor FOXO3, negatively regulated by binding to 14-3-3 protein family, induces MMP9 and MMP13 expression.
This explains the role of FOXO3 in promoting tumor invasion.
PMID:8844971
Molecular mechanism of transcriptional activation of human gelatinase B (=MMP9) by proximal promoter. (NFKB)
em_emtc_emtc_re67( EMT Senescence  map ):
PMID:15592504
PMID:16716598
SP1 and HIF1 complex (HIF2_alpha_ and HIF1_beta_) cooperatively induce MMP1 transcriptional expression
NF-??B is an important transcriptional factor of MT1-MMP expression
em_re1534( EMT Senescence  map ):
PMID:18209571
Roles of MAPK and NF-kappaB in interleukin-6 induction by lipopolysaccharide in vascular smooth muscle cells.
em_re1535( EMT Senescence  map ):
PMID:17784835
IL8 expression is dependent of NF-_kappa_B_ activity
em_re1536( EMT Senescence  map ):
PMID:19215923
The activity of MCP-1 is up-regulated through NF-_kappa_B_
em_re1537( EMT Senescence  map ):
PMID:7706314
Members of the nuclear factor kappa B family transactivate the murine c-myb gene.
em_re1538( EMT Senescence  map ):
PMID:2191300
Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter.
PMID:28536364 c-myc is also transcriptionally upregulated by NF-??B
em_re1540( EMT Senescence  map ):
PMID:15613549
BAX expression was regulated by LMP-1 activation of nuclear factor kappaB
em_re1542( EMT Senescence  map ):
PMID??:9759866
TCDD regulates Fas and FasL promoters through DRE and/or NF-kappaB motifs via AhR.
em_re1544( EMT Senescence  map ):
PMID:18281283
production of NF-kappaB2 p52 is not tumorigenic but predisposes mice to inflammatory autoimmune disease by repressing Bim expression
em_re1546( EMT Senescence  map ):
PMID:11704864
Transcriptional regulation of bcl-2 by nuclear factor kappa B
PMID:20713526
MYC supress the activity of anti-apoptotic BCL2 and BCLXL (BCL2L1) genes
em_re1552( EMT Senescence  map ):
PMID:17533374
HIF-1 and NF-kappaB upregulates CXCR1 and CXCR2 expression

NF-_kappa_B pathway@Nucleus

References
s_shh2_re88:( Survival  map ) PMID:12606705
s_shh2_re92:( Survival  map ) PMID:21228116

Modifications:
In compartment: Cytoplasm
  1. NF-_kappa_B pathway@Cytoplasm map
In compartment: Cytosol
  1. NF-_kappa_B pathway@Cytosol map
In compartment: Nucleus
  1. NF-_kappa_B pathway@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. NF-_kappa_B pathway@Cytosol map → map CSN2*@Cytosol map
    2. NF-_kappa_B_p65*@Cytosol map → map NF-_kappa_B pathway@Cytosol map
    3. NF-_kappa_B pathway@Cytosol map → map IL6@Extracellular space map
    4. NF-_kappa_B pathway@Cytosol map → map CXCL8@Extracellular space map
    5. NF-_kappa_B pathway@Cytosol map → map MCP1*@Extracellular space map
    6. NF-_kappa_B pathway@Cytosol map → map MYB@Cytosol map
    7. NF-_kappa_B pathway@Cytosol map → map MYC@Nucleus map
    8. NF-_kappa_B pathway@Cytosol map → map BAX@Cytosol map
    9. NF-_kappa_B pathway@Cytosol map → map FAS@Cytosol map
    10. NF-_kappa_B pathway@Cytosol map → map XIAP@Cytosol map
    11. ROS@Mitochondria map → map NF-_kappa_B pathway@Cytosol map
    12. MAP3K7@Cytosol map → map NF-_kappa_B pathway@Cytosol map
    13. NF-_kappa_B pathway@Cytosol map → map CXCR2@Cytosol map
    14. RAC1B*@Cytosol map → map NF-_kappa_B pathway@Cytosol map
    15. NF-_kappa_B pathway@Cytosol map → map CXCR1@Cytosol map
    16. rIL1R2@Nucleus map → map NF-_kappa_B pathway@Nucleus map
    17. rS100A9@Nucleus map → map NF-_kappa_B pathway@Nucleus map
    18. NF-_kappa_B pathway@Cytoplasm map → map NFKB1_p50*:​RELA@Nucleus map
    As Catalyser:
    1. gMMP1@Nucleus map → map rMMP1@Nucleus map
    2. gVimentin*@Nucleus map → map rVimentin*@Nucleus map
    3. gTWIST1@Nucleus map → map rTWIST1@Nucleus map
    4. gMMP3@Nucleus map → map rMMP3@Nucleus map
    5. gMMP9@Nucleus map → map rMMP9@Nucleus map
    6. gMMP14@Nucleus map → map rMMP14@Nucleus map
    7. rSNAI1@Nucleus map → map SNAI1@Nucleus map
    8. gBIM*@Nucleus map → map rBIM*@Nucleus map
    9. gBCL2@Nucleus map → map rBCL2@Nucleus map