Identifiers
zinc finger and BTB domain containing 17
HUGO:ZBTB17, HGNC:12936, ENTREZ:7709, GENECARDS:GC01M016268, UNIPROT:Q13105????????
zinc finger and BTB domain containing 17, MIZ1
HUGO:ZBTB17, HGNC:12936, ENTREZ:7709, UNIPROT:Q13105
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / SENESCENCE
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
Cell Cycle DNA Repair / G1_S_CHECKPOINT
References
PMID:9312026, PMID:15095404, PMID:19901969, PMID:19815509
References
em_emtc_emtc_re280( EMT Senescence ):
PMID:11283613
Miz-1 regulates expression of p15INK4b
A Myc???Miz-1 complex binds to the p15 promoter
Myc inhibits binding of p300 to Miz-1
Myc inhibits expression of p15INK4B by binding to Miz-1 (Myc represses p15INK4B by interacting with Miz1)
PMID:11283614
Miz1: a Myc-interacting Zinc-finger protein that recognizes certain transcriptional initiator elements
One of this transcriptional initiator element contains the sequence 5'-CCCACTCTGC corresponding to the p15INK4B transcriptional intiator
em_emtc_emtc_re281( EMT Senescence ):
Physical interaction between Smad proteins and Miz-1:
-Immunoprecipitation of endogenous Smad2 and Smad3 followed by anti-Miz western bloting provided evidence for an association
-This association was stimulated by addition of TGFB
-Interaction was observed between Miz1 and Smad3 and Smad4 but no clear interaction was observed between Miz1 and Smad2
-Smad3 and weakly Smad4 can directly and selectively bind to Miz1 through the MH1 domain
-Although Sp1-Smad interactions have been reported, Sp1 does not directly bind to Miz1, even in the presence of TGFB.
-The Smad-interaction region of Miz1 does not overlap with the Myc-interaction region.
-Myc did not inhibit the Smad-Miz1 interaction
-Miz1 can bridge Smad proteins and Myc when these proteins coexist.
+ MIZ1*@Nucleus + PKMYT1@Nucleus → ce_s2499
+ MYC@Nucleus → MIZ1*:MYC@Nucleus
+ (SMAD2|S467_pho|S464_pho|S465_pho:SMAD3|S422_pho|S423_pho|S425_pho:SMAD4:SP1)|active@Nucleus → (MIZ1*:SMAD2|S467_pho|S464_pho|S465_pho:SMAD3|S422_pho|S423_pho|S425_pho:SMAD4:SP1)|active@Nucleus