Gene MIR17-92* map

Identifiers
miR-17-92 cluster host gene (non-protein coding)
HUGO:MIR17HG HGNC:23564 ENTREZ:407975 UNIPROT:Q75NE6
microRNA 17-92 cluster
HUGO:MIR17HG HGNC:23564 ENTREZ:407975 UNIPROT:Q75NE6 GENECARDS:MIR17HG KEGG:407975 ATLASONC:GC_MIR17HG WIKI:MIR17HG

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / HEDGEHOG  map

References
PMID:20885820
PMID:17060945

gMIR17-92*@Nucleus

References
rc_re146( Regulated Cell Death  map ):
PMID:18328430
MIR17HG transactivation by E2F1
PMID:15944709
MIR17-92 cluster transactivation by MYC
PMID:19696742
MIR17HG transactivation repressed by TP53. Proposed mechanism: TP53- and TBP- binding sites overlaps.
in human colorectal carcinoma HCT116 (TP53 competent cells), MIR17HG repression upon hypoxia and TP53 stabilization.
in human colorectal carcinoma cells HCT116 and LOVO, this effect is blocked by siRNA against TP53
in HCT116 and LOVO, siRNA against MYC represses MIR17-92 expression

Modifications:
In compartment: Nucleus
  1. gMIR17-92*@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gMIR17-92*@Nucleus map → map arMIR17-92*@Nucleus map
    2. gMIR17-92*@Nucleus map → map arMIR17-5P*@Nucleus map
    3. gMIR17-92*@Nucleus map → map arMIR20A@Nucleus map
    4. gMIR17-92*@Nucleus map → map arMIR18A@Nucleus map
    5. gMIR17-92*@Nucleus map → map arMIR19A@Nucleus map
    6. gMIR17-92*@Nucleus map → map arMIR19B1@Nucleus map
    7. gMIR17-92*@Nucleus map → map arMIR92A1@Nucleus map
    8. gMIR17-92*@Nucleus map → map arMIR17-3P*@Nucleus map
    As Catalyser: