Reaction state_transition su_mpk1_mpk1_re279 map

MYC@Nucleus map → Proliferation@Cytoplasm map

Reaction regulators:
Catalysis
  1. MAX|​pho@Cytoplasm map
Inhibition
  1. GSK3_beta_*@Cytoplasm map


References
MAX interacts with the transcription factor C-MYC enabling C-MYC to trans-activate at least a subset of its target genes.
GSK3 is constitutively active in unstimulated cells and phosphorylates many proteins (including glycogen synthase C-MYC and cyclin D) to keep them in inactive states or promote their degradation.
PMID:11274345 PMID:12040186