Antisense RNA MIR17-92* map

Identifiers
miR-17-92 cluster host gene (non-protein coding)
HUGO:MIR17HG HGNC:23564 ENTREZ:407975 UNIPROT:Q75NE6

arMIR17-92*@Nucleus

References
rc_re146( Regulated Cell Death  map ):
PMID:18328430
MIR17HG transactivation by E2F1
PMID:15944709
MIR17-92 cluster transactivation by MYC
PMID:19696742
MIR17HG transactivation repressed by TP53. Proposed mechanism: TP53- and TBP- binding sites overlaps.
in human colorectal carcinoma HCT116 (TP53 competent cells), MIR17HG repression upon hypoxia and TP53 stabilization.
in human colorectal carcinoma cells HCT116 and LOVO, this effect is blocked by siRNA against TP53
in HCT116 and LOVO, siRNA against MYC represses MIR17-92 expression
rc_re105( Regulated Cell Death  map ):
PMID:16166262
PMID:23070007
in chronic lymphocytic leukemia human cells
rc_re147:( Regulated Cell Death  map ) PMID:15136036

Modifications:
In compartment: Nucleus
  1. arMIR17-92*@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gMIR17-92*@Nucleus map → map arMIR17-92*@Nucleus map
    2. arMIR17-92*@Nucleus map → map arMIR17@Cytosol map + arMIR18A@Cytosol map + arMIR19A@Cytosol map + arMIR20A@Cytosol map + arMIR19B1@Cytosol map + arMIR92A1@Cytosol map
    As Catalyser:
    1. rBCL2@Nucleus map → map BCL2@Cytosol map
    2. rCDKN1A@Nucleus map → map CDKN1A@Cytosol map