Identifiers
HUGO:PTP4A3
protein tyrosine phosphatase type IVA, member 3
HUGO:PTP4A3 HGNC:9636 ENTREZ:11156 UNIPROT:O75365
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / ECM
References
PMID:24376839
PTP4A3 is implicated in cell adhesion and the regulation of focal adhesion components including integrin beta-1, Src, paxillin and p130Cas
Similarly, PTP4A3 promotes cell invasion by increasing MMP2 activity and decreasing the expression of the MMP inhibitor, TIMP2.
PTP4A3 is also involved in EMT: PTP4A3 overexpression in colorectal carcinoma cells downregulates epithelial markers (E-cadherin, plakoglobin, and integrin beta-3) and upregulates expression of mesenchymal markers (fibronectin and snail1).
PMID:23691193
Src-mediated phosphorylation of PTP4A3 Is required for Rho activation, motility and invasion promoted by PTP4A3.
http://d-scholarship.pitt.edu/18634/1/Zimmerman_ETD-2013.pdf
c-MYC activity was able to increase Ptp4a3 gene expression in a fibroblast cell culture model.
Tumors from the Ptp4a3-null mice had elevated levels of both IGF1R?? and c-MYC compared to tumors replete with PTP4A3.
Ptp4a3-null cells displayed less migration compared to wildtype cells and loss of VEGF-induced phosphorylation of SRC protein.
Reduced migration and SRC activation were also observed when human endothelial cells were treated with a small molecule inhibitor of PTP4A3.
References
mo_re20:( motility ) PMID:21053359 PMID:18471976 PMID:21084277 PMID:23178297 PMID:20609352 PMID:22073279 PMID:22970020 PMID:21811102 PMID:25139404 PMID:24403062 PMID:27526109 PMID:27222233