Identifiers
BMI1 polycomb ring finger oncogene
HUGO:BMI1, HGNC:1066, ENTREZ:648, GENECARDS:GC10P022605
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / SENESCENCE
References
PMID:21224848
PMID:11283614
Myc: an ubiquitous mediator of cell growth and proliferation
Myc can both activate and repress transcription, depending on the nature of associated factors
TGFB downregulates Myc to cause cell cycle arrest.
TGFB activates p15INK4B and/or p21CIP1 (inhibitor of CDKs) ==> CDK inhibition by TGFB
TGFB downregulates cdc25A (a phosphatase, activator of CDKs) ==> CDK inhibition by TGFB
PMID:2191300
Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter.
PMID??:28536364
c-myc is transcriptionally upregulated by NF-??B
PMID:20027199
MYC induces DNA damage throuh an increase in ROS production, innapropriate DNA synthesis and abrogation of DNA repair
PMID:20713526
MYC supress the activity of anti-apoptotic BCL2 and BCLXL (BCL2L1) genes
PMID??:20713526
MYC in complex with CDK2 alone inhibit senescence through the inhibition of p16 and p21 expression as well as TERT and BMI1 expression increase. MYC in complex with CDK2 and p27KIP1 induces senescence through the expression increase of p16 and p21 as well as TERT and BMI1 expression decrease. WRN inhibit MYC induced senescence.
PMID??: PMID:17055429
MYC stimulate P53 and ARF
References
em_emtc_emtc_re1197( EMT Senescence ):
PMID:21919891
PMID:21733352
Direct activation of Bmi1 expression by Twist1 using transient transfection.
PMID:20818389
Twist1 directly activates BMI1 transcription by binding to the E-box in intron 1 of the BMI1 gene.
PMID:17550342
SNAI2 induces BMI1 expression
PMID:11283614
Myc: an ubiquitous mediator of cell growth and proliferation
Myc can both activate and repress transcription, depending on the nature of associated factors
TGFB downregulates Myc to cause cell cycle arrest.
TGFB activates p15INK4B and/or p21CIP1 (inhibitor of CDKs) ==> CDK inhibition by TGFB
TGFB downregulates cdc25A (a phosphatase, activator of CDKs) ==> CDK inhibition by TGFB
PMID:2191300
Interaction of an NF-kappa B-like factor with a site upstream of the c-myc promoter.
PMID??:28536364
c-myc is transcriptionally upregulated by NF-??B
PMID:20027199
MYC induces DNA damage throuh an increase in ROS production, innapropriate DNA synthesis and abrogation of DNA repair
PMID:20713526
MYC supress the activity of anti-apoptotic BCL2 and BCLXL (BCL2L1) genes
PMID??:20713526
MYC in complex with CDK2 alone inhibit senescence through the inhibition of p16 and p21 expression as well as TERT and BMI1 expression increase. MYC in complex with CDK2 and p27KIP1 induces senescence through the expression increase of p16 and p21 as well as TERT and BMI1 expression decrease. WRN inhibit MYC induced senescence.
PMID??: PMID:17055429
MYC stimulate P53 and ARF
em_emtc_emtc_re1198( EMT Senescence ):
PMID:19935649
Protein expression of Bmi1, Sox2, p63 was reduced after ZEB1 knockdown.
ZEB1 knockdown not only resulted in reduced invasion and metastasis, but also in reduced tumorigenicity.
ZEB1 is also necessary for the self-renewing capacity.
ZEB1 is crucial for drug resistance in pancreatic cancer cells. This supports data showing that EMT activators (Twist and Snail) confer anti-apoptotic properties
→ rBMI1@Nucleus
→ rBMI1@Nucleus
→ rBMI1@Nucleus
→ BMI1@Cytosol