Protein p14ARF* map

Identifiers
HUGO:CDKN2A
cyclin-dependent kinase inhibitor 2A
HUGO:CDKN2A HGNC:1787 ENTREZ:1029 UNIPROT:P42771

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / SENESCENCE  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

References
PMID??: PMID:17055429
MYC stimulate P53 and p14ARF
PMID:24954210
p14ARF inhibit MDM2
PMID??:24954210??
DNA damage may reduce ARF (=p14 ARF) protein levels by inducing its degradation
uniprot:Q8N726

p14ARF*@Cytosol

References
mo_re300:( motility  map ) PMID:29435006
mo_re6:( motility  map ) PMID:21084277 PMID:19945467 PMID:29435006

p14ARF*@Nucleus

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

References
rc_re449:( Regulated Cell Death  map ) PMID:16508011
rc_re457:( Regulated Cell Death  map ) PMID:15989956
rc_re671( Regulated Cell Death  map ):
PMID:15199070
ARF binds to and inhibits MYC, in a p53 independent manner. ARF induces MYC localization to nucleolus
rc_re1127( Regulated Cell Death  map ):
PMID:19590512
Siva1 and mdm2
PMID:15989956
HUWE1
PMID:19960022
effect of SIRT1 K382-deacetylation
rc_re1172( Regulated Cell Death  map ):
PMID:20208519
TRIP12 is a E3 ubiquitin ligase for ARF
MYC, independently of its DNA binding domain, inhibits TRIP12-mediated ARF degradation through direct interaction with TRIP12
Nucleophosmin protects ARF from TRIP12-mediated ubiquitination by targeting it to the nucleolus

p14ARF*|​ubi@Nucleus

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

References
rc_re1172( Regulated Cell Death  map ):
PMID:20208519
TRIP12 is a E3 ubiquitin ligase for ARF
MYC, independently of its DNA binding domain, inhibits TRIP12-mediated ARF degradation through direct interaction with TRIP12
Nucleophosmin protects ARF from TRIP12-mediated ubiquitination by targeting it to the nucleolus

p14ARF*@Nucleolus

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DNA_DAMAGE_RESPONSE  map
 Regulated Cell Death  map  / MOMP_REGULATION  map
 Regulated Cell Death  map  / RCD_GENES  map

References
rc_re1390:( Regulated Cell Death  map ) PMID:20208519

Modifications:
In compartment: Cytosol
  1. p14ARF*@Cytosol map
In compartment: Nucleolus
  1. p14ARF*@Nucleolus map
In compartment: Nucleus
  1. p14ARF*@Nucleus map
  2. p14ARF*|​ubi@Nucleus map
Participates in complexes:
In compartment: Nucleus
  1. HECTH9*:​p14ARF*@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. rp14ARF*@Nucleus map → map p14ARF*@Cytosol map
  2. p14ARF*@Cytosol map → map degraded
  3. rp14ARF*@Nucleus map → map p14ARF*@Cytosol map
  4. p14ARF*@Nucleus map → map p14ARF*|​ubi@Nucleus map
  5. p14ARF*|​ubi@Nucleus map → map degraded
  6. p14ARF*@Nucleus map → map p14ARF*@Nucleolus map
  7. rp14ARF*@Nucleus map → map p14ARF*@Nucleus map
  8. p14ARF*@Nucleus map + HECTH9*@Nucleus map → map HECTH9*:​p14ARF*@Nucleus map
  9. MYC@Nucleus map + p14ARF*@Nucleus map → map rc_s3238
As Catalyser:
  1. gMDM2@Nucleus map → map rMDM2@Nucleus map
  2. p53*@Cytosol map → map p53*|​ubi@Cytosol map
  3. p53*|​S15_pho|​active@Nucleus map → map p53*@Nucleus map
  4. CTBP*@Nucleus map → map degraded