Phenotype Proliferation map
Proliferation@Cytosol

References
mo_re293:( motility  map ) PMID:22995644

Proliferation@Cytoplasm

Maps_Modules
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
Proliferation
su_mpk1_mpk1_re279( Survival  map ):
MAX interacts with the transcription factor C-MYC enabling C-MYC to trans-activate at least a subset of its target genes.
GSK3 is constitutively active in unstimulated cells and phosphorylates many proteins (including glycogen synthase C-MYC and cyclin D) to keep them in inactive states or promote their degradation.
PMID:11274345 PMID:12040186
su_mpk1_mpk1_re280( Survival  map ):
PDK1 is a PI3K target leading to activation of P70 and subsequent cell growth.
PMID:12040186

Proliferation@Nucleus

References
su_wnc1_s_wnc1_re141( Survival  map ):
Activated Daam1 is responisble for the inhibition
PMID:20351293
su_shh1_s_shh1_re86( Survival  map ):
PMID:11331587
PMID:16489008
su_shh1_s_shh2_re29:( Survival  map ) PMID:20678582 PMID:21034673
su_shh1_s_shh2_re41:( Survival  map ) PMID:20712011
su_shh1_s_shh2_re44:( Survival  map ) PMID:20348948 PMID:19960541
su_shh1_s_shh2_re50:( Survival  map ) PMID:19055944
su_shh1_s_shh2_re56:( Survival  map ) PMID:19581346
su_shh1_s_shh2_re59:( Survival  map ) PMID:19736394
su_shh1_s_shh2_re75:( Survival  map ) PMID:16054035
su_shh1_s_shh2_re76:( Survival  map ) PMID:19574535
su_shh1_s_shh2_re85:( Survival  map ) PMID:16977332
su_shh1_s_shh2_re151( Survival  map ):
PMID:18700987
The miR-17-5p drives the cell from G1 to S phase thereby regulating more than 20 genes

Proliferation@Nucleus

References
s_shh1_re86( Survival  map ):
PMID:11331587
PMID:16489008
s_wnc1_re141( Survival  map ):
Activated Daam1 is responisble for the inhibition
PMID:20351293

Proliferation@Nucleus

References
s_shh2_re29:( Survival  map ) PMID:20678582 PMID:21034673
s_shh2_re41:( Survival  map ) PMID:20712011
s_shh2_re44:( Survival  map ) PMID:20348948 PMID:19960541
s_shh2_re50:( Survival  map ) PMID:19055944
s_shh2_re56:( Survival  map ) PMID:19581346
s_shh2_re59:( Survival  map ) PMID:19736394
s_shh2_re75:( Survival  map ) PMID:16054035
s_shh2_re76:( Survival  map ) PMID:19574535
s_shh2_re85:( Survival  map ) PMID:16977332
s_shh2_re151( Survival  map ):
PMID:18700987
The miR-17-5p drives the cell from G1 to S phase thereby regulating more than 20 genes

Modifications:
In compartment: Cytoplasm
  1. Proliferation@Cytoplasm map
In compartment: Cytosol
  1. Proliferation@Cytosol map
In compartment: Nucleus
  1. Proliferation@Nucleus map
  2. Proliferation@Nucleus map
  3. Proliferation@Nucleus map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. G2 phase@Cytosol map → map Proliferation@Cytosol map
    2. GJA1:​ZO2*@Cytosol map → map Proliferation@Cytosol map
    3. AKT1|​ser473_pho|​active@Cytosol map → map Proliferation@Cytosol map
    4. Autophagy@Cytosol map → map Proliferation@Cytosol map
    5. PTP4A3|​Y53_unk|​pre@Cytosol map → map Proliferation@Cytosol map
    6. Proliferation@Cytosol map → map Cell cycle / survival / proliferation@Cytosol map
    7. Proliferation@Cytosol map → map Cell cycle / survival / proliferation@Cytosol map
    8. MYC@Nucleus map → map Proliferation@Cytoplasm map
    9. p70_alpha_*|​pho@Cytoplasm map → map Proliferation@Cytoplasm map
    10. CyclinB*@Nucleus map → map Proliferation@Nucleus map
    11. arMIR17-5P*@Nucleus map → map Proliferation@Nucleus map
    12. rFOXL1@Nucleus map → map Proliferation@Nucleus map
    13. rFOXP3@Nucleus map → map Proliferation@Nucleus map
    14. rFOXM1@Nucleus map → map Proliferation@Nucleus map
    15. rTBX2@Nucleus map → map Proliferation@Nucleus map
    16. rSIX1@Nucleus map → map Proliferation@Nucleus map
    17. rNKX2-2@Nucleus map → map Proliferation@Nucleus map
    18. rIGFBP6@Nucleus map → map Proliferation@Nucleus map
    19. rMYCN@Nucleus map → map Proliferation@Nucleus map
    20. rCyclinD*@Nucleus map → map Proliferation@Nucleus map
    21. rJUN@Nucleus map → map Proliferation@Nucleus map
    22. JUNB@Nucleus map → map Proliferation@Nucleus map
    23. JUN@Nucleus map → map Proliferation@Nucleus map
    24. RHOA:​ROCK*@Cytoplasm map → map Proliferation@Nucleus map
    As Catalyser: