Identifiers
MYC associated factor X
HUGO:MAX
HUGO:MAX, HGNC:6913, ENTREZ:4149, UNIPROT:P61244
"MAX protein"

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair   / G1_S_CHECKPOINT 
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / MITOCHONDRIAL_GENES 
 Regulated Cell Death   / RCD_GENES 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / MAPK 

References
PMID:2006410, PMID:15121849, PMID:8425218, PMID:16908182
MAX interacts with the transcription factor C-MYC enabling C-MYC to trans-activate at least a subset of its target genes. MAX is phosphorylated by P38 through complex formation (not represented here).
PMID:11274345

References
su_mpk1_mpk1_re166( Survival  ):
MAX is phosphorylated by P38 through complex formation (not represented here).
PMID:11274345

References
su_mpk1_mpk1_re166( Survival  ):
MAX is phosphorylated by P38 through complex formation (not represented here).
PMID:11274345
su_mpk1_mpk1_re279( Survival  ):
MAX interacts with the transcription factor C-MYC enabling C-MYC to trans-activate at least a subset of its target genes.
GSK3 is constitutively active in unstimulated cells and phosphorylates many proteins (including glycogen synthase C-MYC and cyclin D) to keep them in inactive states or promote their degradation.
PMID:11274345 PMID:12040186

1. MAX@Cytoplasm
2. MAX|​pho@Cytoplasm

1. MAX@Nucleus

1. MAX:​MXD1@Nucleus

1. te_s488 + MXD1@Nucleus → MAX:​MXD1@Nucleus
2. MAX@Cytoplasm → MAX|​pho@Cytoplasm
3. MXD1@Nucleus + MAX@Nucleus → MAX:​MXD1@Nucleus
4. MYC@Nucleus + MAX@Nucleus → te_s488

1. MYC@Nucleus → Proliferation@Cytoplasm
2. gTERT@Nucleus → rTERT@Nucleus