Identifiers
HUGO:CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
HUGO:CDKN1A, HGNC:1784, ENTREZ:1026, GENECARDS:GC06P036649
HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936
CDKN1
HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / ANTIOXIDANT_RESPONSE
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / RCD_GENES
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
Survival / PI3K_AKT_MTOR
References
PMID:9618481
p21 is regulated by 3 classes of signals that result in arrest of cell growth:
(i) p53 (activated by DNA damage), p73, or the tumor suppressor protein BRCA1.
(ii) Extracellular growth factors acting in a p53-independent mechanism, e.g. TGFB
(iii) Factors that induce cellular differentiation
-Smad4 transactivated the proximal p21 promoter 1.3-fold
-Smad2 transactivated the proximal p21 promoter 3-fold
-Smad2/4 transactivated the proximal p21 promoter 12-fold
-Smad3 transactivated the proximal p21 promoter 25-fold
-Smad3/Smad2 transactivated the proximal p21 promoter 40-fold
-Smad3/Smad4 transactivated the proximal p21 promoter 110-fold
-Smad2/Smad3/Smad4 transactivated the proximal p21 promoter 140-fold
Smad proteins act as Transcriptional Activators via functional interactions with the Transcription factor Sp1
synonym:p21 synonym:CIP1 synonym:WAF1
PMID:19440234
PMID:20673124
References
mo_re40:( motility ) PMID:18471976 PMID:19945467 PMID:27328425
→ rp21CIP1*@Nucleus
→ rp21CIP1*@Nucleus
→ rp21CIP1*@Nucleus
→ gp21CIP1*@Nucleus
→ p21CIP1*@Nucleus
→ gp21CIP1*@Nucleus