Identifiers
HUGO:GLS
References
MODULE METABOLIC
PMID:25002027
SQSTM1 (p62) p62
We also observed a decrease in the direct conversion of [U-13C5] glutamine to glutamate in p62 KO fibroblasts, with a relative increase in the fraction of glutamate derived from [1,2-13C2]glucose
and reduced levels of the glutamine transporters SLC7A5 and SLC1A5, as well as glutaminase-1 (GLS1) (Figure 4O), a critical enzyme in the pathway that catalyzes the conversion of glutamine into glutamate
p62 regulates GLS expression via mTOR/myc pathway