Protein PDPK1 map

Identifiers
HUGO:PDK1
pyruvate dehydrogenase kinase 1
HUGO:PDK1 hgnc_id:HGNC:8809 HGNC:8809 ENTREZ:5163 UNIPROT:Q15118
3-phosphoinositide dependent protein kinase-1
HUGO:PDPK1 HGNC:8816 ENTREZ:5170 UNIPROT:O15530
HUGO:PDPK1 HGNC:8816 ENTREZ:5170 UNIPROT:O15530 GENECARDS:PDPK1 REACTOME:61460 KEGG:5170 ATLASONC:GC_PDPK1 WIKI:PDPK1

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CORE  map
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / MITOCHONDRIA_OXIDATIVE_STRESS  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / CASPASES  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:12670391 PMID:19122654 PMID:15802604
CASCADE:PDGF
PMID:11687500
Binding to second messenger lipids allows PDK1 and AKT (PKB) to interact with each other, resulting in the phosphorylation and consequent activation of AKT (PKB).
PMID:11747822
Akt but not SGK promotes cell motility downstream of the PI3-K-PDK1 pathway.
PMID:18802401
PMID:17680028
synonym:PDK1PMID:17604717
 MACROPHAGE  map
CASCADE:IL4
PMID:19109239
IL4 induces he tyrosine phosphorylation of IRS-2 via Type I IL-4 Receptors. Activated IRS2 interacts with p85 subunit of PI3K and Grb2 and activates downstrean PI3K signaling (??phosphorylation of Akt on Ser473)

PDPK1|​S241_pho|​active@Cytoplasm

References
s_akt1_re68:( Survival  map ) PMID:16286006
s_akt1_re85:( Survival  map ) PMID:11500365
s_akt1_re194:( Survival  map ) PMID:20932932

PDPK1@Lipid Raft

References
s_akt1_re7( Survival  map ):
PMID:18802401
PMID:17680028

Modifications:
In compartment: Cytoplasm
  1. PDPK1@Cytoplasm map
  2. PDPK1|​S241_pho|​active@Cytoplasm map
In compartment: Cytosol
  1. PDPK1@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PDPK1@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Lipid Raft
  1. PDPK1@Lipid Raft map
In compartment: T_cell
  1. PDPK1@T_cell map
Participates in complexes:
In compartment: Cytosol
  1. PDPK1:​PIP3*@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PDPK1:​PIP3*@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Lipid Raft
  1. PDPK1|​S241_pho:​PI3,4,5-P3@Lipid Raft map
In compartment: T_cell
  1. PDPK1:​PIP3*@T_cell map
In compartment: cSMAC
  1. PDPK1:​PIP3*@cSMAC map
Participates in reactions:
As Reactant or Product:
  1. PDPK1@T_cell map + PIP3*@T_cell map → map PDPK1:​PIP3*@T_cell map
  2. PDPK1:​PIP3*@T_cell map → map PDPK1:​PIP3*@cSMAC map
  3. PDPK1@Cytosol map + PIP3*@Cytosol map → map PDPK1:​PIP3*@Cytosol map
  4. PDPK1@INNATE_IMMUNE_CELL_Cytosol map + PIP3*@INNATE_IMMUNE_CELL_Cytosol map → map PDPK1:​PIP3*@INNATE_IMMUNE_CELL_Cytosol map
  5. PDPK1@Cytosol map + PIP3*@Cytosol map → map PDPK1:​PIP3*@Cytosol map
  6. PDPK1@Cytoplasm map → map PDPK1|​S241_pho|​active@Cytoplasm map
  7. PI3,4,5-P3@Lipid Raft map + PDPK1@Lipid Raft map → map PDPK1|​S241_pho:​PI3,4,5-P3@Lipid Raft map
As Catalyser:
  1. AKT*|​Thr450_pho@T_cell map → map AKT*|​Thr308_pho|​Thr450_pho@T_cell map
  2. DAG:​PRKCQ@cSMAC map → map (DAG:​PRKCQ|​pho)|​active@cSMAC map
  3. AKT*@Cytosol map → map AKT*|​pho|​active@Cytosol map
  4. AKT*@INNATE_IMMUNE_CELL_Cytosol map → map AKT*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. AKT*@Cytosol map → map AKT*|​S473_pho|​T308_pho@Cytosol map
  6. AKT*@Cytosol map → map AKT*|​S473_pho|​T308_pho@Cytosol map
  7. p70_beta_*|​T388_pho@Cytoplasm map → map p70_beta_*|​T388_pho|​T228_pho|​active@Cytoplasm map
  8. PI3,4,5-P3@Lipid Raft map + AKT1|​T450_pho|​S473_emp|​active@Cytoplasm map → map AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft map
  9. p70_alpha_*|​T389_pho@Cytoplasm map → map p70_alpha_*|​T389_pho|​T229_pho|​active@Cytoplasm map
  10. PDPK1@Cytoplasm map → map PDPK1|​S241_pho|​active@Cytoplasm map
  11. SGK1|​S442_pho@Cytoplasm map → map SGK1|​T256_pho|​S442_pho|​active@Cytoplasm map