Identifiers
HUGO:IL4R
Maps_Modules
MODULE:MACROPHAGE
MODULE:MDSC
MODULE:IMMUNOSUPPRESSIVE_CYTOKINE_PATHWAYS
References
PMID:14610620, PMID:12223527
IL13 acts via IL4 receptor type 2, which contains two subunits IL4R and IL13RA1
PMID:23124025, PMID:20856220
In human monocytes, IL-4 mediates its effect through the
type I IL-4R, composed of the IL-4R????and common gamma-chain (IL-2R??);
And, probably through type II IL-4Ris composed of the
IL-4Ra chain and IL-13Ra1
PMID: 24030977
SCF2 (GM-CSF) promotes the immunosuppressive activity of glioma-infiltrating myeloid cells (MDSC) through upregulation of expression of interleukin-4 receptor-??
ARG1, TGFB, COX2 expression is downregulated in IL4R-/- MDSC (probably via STAT3 and MYC).
IL4R@Membrane
Identifiers_begin:
Identifiers_end
Maps_Modules_begin:
Maps_Modules_end
References_begin:
+ IL4R@Membrane → IL2RG:IL4R@Membrane
+ IL4R@Membrane → IL13RA1:IL4R@Membrane
+ IL2RG:IL4R@Membrane + JAK3@Cytosol + JAK2@Cytosol + JAK1@Cytosol → IL2RG:IL4:IL4R:JAK1|pho:JAK2:JAK3@Membrane
+ IL13RA1:IL4R@Membrane + JAK1@Cytosol + JAK2@Cytosol + TYK2@Cytosol → IL13:IL13RA1|pho:IL4R|pho:JAK1:JAK2|pho:TYK2|pho@Membrane
+ IL13RA1:IL4R@Membrane + JAK1@Cytosol + JAK2@Cytosol + TYK2@Cytosol → IL13RA1:IL4:IL4R:JAK1|pho:JAK2:TYK2@Membrane
→ IL4R@Membrane