Protein MAP3K5 map

Identifiers
mitogen-activated protein kinase kinase kinase 5
MEKK5
HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 GENECARDS:MAP3K5 KEGG:4217 ATLASONC:GC_MAP3K5 WIKI:MAP3K5
HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
PMID:11274345
PMID:12655147
ASK1 is a MAP3K and can activate both JNK and P38 pathways.
TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1.
PMID:12556535
IGF1R signaling suppresses the ASK1-mediated stimulation of JNK/p38 thus supresses the induction of apoptosis.
PMID:11274345 PMID:12655147

MAP3K5@Cytosol

References
em_emtc_emtc_re1621( EMT Senescence  map ):
PMID:11274345
PMID:12655147
ASK1 is a MAP3K and can activate both JNK and P38 pathways.
TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1.
PMID:12556535
IGF1R signaling suppresses the ASK1-mediated stimulation of JNK/p38 thus supresses the induction of apoptosis.

MAP3K5|​pho@Cytosol

References
em_emtc_emtc_re1621( EMT Senescence  map ):
PMID:11274345
PMID:12655147
ASK1 is a MAP3K and can activate both JNK and P38 pathways.
TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1.
PMID:12556535
IGF1R signaling suppresses the ASK1-mediated stimulation of JNK/p38 thus supresses the induction of apoptosis.

MAP3K5@Cytoplasm

References
su_mpk1_mpk1_re144( Survival  map ):
TNF-dependent production of ROS triggers the dissociation of Trx from ASK1.
PMID:12655147
su_mpk1_mpk1_re147( Survival  map ):
TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1.

Modifications:
In compartment: Cytoplasm
  1. MAP3K5@Cytoplasm map
In compartment: Cytosol
  1. MAP3K5@Cytosol map
  2. MAP3K5|​pho@Cytosol map
Participates in complexes:
In compartment: Cytoplasm
  1. MAP3K5:​TXN@Cytoplasm map
  2. MAP3K5|​pho:​TNFRSF1B:​TRAF2@Cytoplasm map
  3. MAP3K5|​pho:​RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm map
Participates in reactions:
As Reactant or Product:
  1. MAP3K5@Cytosol map → map MAP3K5|​pho@Cytosol map
  2. MAP3K5@Cytosol map → map Apoptosis@Cytosol map
  3. MAP3K5:​TXN@Cytoplasm map → map MAP3K5@Cytoplasm map + TXN@Cytoplasm map
  4. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map + MAP3K5@Cytoplasm map → map MAP3K5|​pho:​RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm map
  5. TNFRSF1B:​TRAF2@Plasma Membrane map + MAP3K5@Cytoplasm map → map MAP3K5|​pho:​TNFRSF1B:​TRAF2@Cytoplasm map
As Catalyser:
  1. MAP2K4@Cytoplasm map → map MAP2K4|​pho|​pho@Cytoplasm map
  2. MAP2K3@Cytoplasm map → map MAP2K3|​pho|​pho@Cytoplasm map
  3. MAP2K7@Cytoplasm map → map MAP2K7|​pho|​pho@Cytoplasm map
  4. MAP2K6@Cytoplasm map → map MAP2K6|​pho|​pho@Cytoplasm map