Protein TAB2 map

Identifiers
TGF-beta activated kinase 1/MAP3K7 binding protein 2
HUGO:TAB2 hgnc_id:HGNC:17075 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8
HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8
HUGO:TAB2
MAP3K7IP2 "mitogen-activated protein kinase kinase kinase 7 interacting protein 2"
HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 GENECARDS:TAB2 REACTOME:168084 KEGG:23118 ATLASONC:GC_TAB2 WIKI:TAB2

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CORE  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / TNF_RESPONSE  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / IMMUNOSTIMULATORY_CORE_PATHWAYS  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:12620219
IRAK-1 interacts with the downstream adaptor TRAF6,
resulting in formation of a complex that also includes TAK1 and TAB2.
IRAK-1 mediates the translocation of TRAF6, TAK1 and TAB2 to the cytosol,
where they form a multiprotein complex with other cytosolic proteins,
which are needed for stimulation of TAK1 kinase activity.
PMID:14660645, PMID:18264787, PMID:12620219

TAB2@Nucleus

References
s_wca3_re25:( Survival  map ) PMID:20194509

Modifications:
In compartment: Cytosol
  1. TAB2@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. TAB2@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. TAB2@Nucleus map
Participates in complexes:
In compartment: Cytoplasm
  1. TAB1:​TAB2:​TAK1*|​emp@Cytoplasm map
  2. TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map
  3. RCAN*|​S94_pho|​S136_pho:​TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map
  4. FZD*:​ROR2|​pho:​TAB1:​TAB2:​TAK1*|​pho:​WNT3@Cytoplasm map
In compartment: Cytosol
  1. (MAP3K7:​TAB2:​TAB3)|​active@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. (MAP3K7:​TAB2:​TAB3)|​active@INNATE_IMMUNE_CELL_Cytosol map
In compartment: Nucleus
  1. NLK|​T286_pho|​hm2:​TAB1:​TAB2:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. MAP3K7@Cytosol map + TAB2@Cytosol map + TAB3@Cytosol map → map (MAP3K7:​TAB2:​TAB3)|​active@Cytosol map
  2. MAP3K7@INNATE_IMMUNE_CELL_Cytosol map + TAB2@INNATE_IMMUNE_CELL_Cytosol map + TAB3@INNATE_IMMUNE_CELL_Cytosol map → map (MAP3K7:​TAB2:​TAB3)|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. TAB2@Cytosol map → map TAB*@Cytosol map
  4. TAB1:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus map + NLK|​T286_pho|​hm2|​active@Nucleus map + TAB2@Nucleus map → map NLK|​T286_pho|​hm2:​TAB1:​TAB2:​TAK1*|​T184_pho|​T178_pho|​pho|​S192_pho@Nucleus map
  5. TGF-_beta_ pathway@Extracellular space map → map TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map
  6. RCAN*|​T192_pho@Cytoplasm map + TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map → map RCAN*|​S94_pho|​S136_pho:​TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map
  7. TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map → map TAB1:​TAB2:​TAK1*|​emp@Cytoplasm map
  8. TAB1:​TAB2:​TAK1*|​pho@Cytoplasm map + FZD*:​ROR2|​pho:​WNT3@Cytoplasm map → map FZD*:​ROR2|​pho:​TAB1:​TAB2:​TAK1*|​pho:​WNT3@Cytoplasm map
  9. FZD*:​ROR2|​pho:​TAB1:​TAB2:​TAK1*|​pho:​WNT3@Cytoplasm map → map WNT canonical pathway@Cytoplasm map
As Catalyser:
  1. IKBKG:​IKK_alpha_*:​IKK_beta_*@Cytosol map → map IKBKG|​ubi:​IKK_alpha_*:​IKK_beta_*|​pho@Cytosol map
  2. IKK_alpha_*|​hm2@INNATE_IMMUNE_CELL_Cytosol map → map IKK_alpha_*|​pho|​hm2|​active@INNATE_IMMUNE_CELL_Cytosol map
  3. IKBKG:​IKK_alpha_*:​IKK_beta_*@INNATE_IMMUNE_CELL_Cytosol map → map IKBKG|​ubi:​IKK_alpha_*:​IKK_beta_*|​pho@INNATE_IMMUNE_CELL_Cytosol map
  4. MAP2K4@INNATE_IMMUNE_CELL_Cytosol map → map MAP2K4|​pho@INNATE_IMMUNE_CELL_Cytosol map
  5. MAP2K3@INNATE_IMMUNE_CELL_Cytosol map → map MAP2K3|​pho@INNATE_IMMUNE_CELL_Cytosol map
  6. LEF_TCF*@Nucleus map → map LEF_TCF*|​S166_pho|​T155_pho@Nucleus map
  7. Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​TNPO1:​Tubulin-_alpha_*@Cytoplasm map → map Ca2+:​Calmodulin*:​KPNB1:​NFAT*:​PPP3CB:​PPP3R*:​Tubulin-_alpha_*@Nucleus map
  8. FZD*:​ROR2:​WNT3@Cytoplasm map → map FZD*:​ROR2|​pho:​WNT3@Cytoplasm map