Identifiers
HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 GENECARDS:MAPK8 HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 GENECARDS:MAPK9 HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 GENECARDS:MAPK10
mitogen-activated protein kinase 8
HUGO:MAPK8 hgnc_id:HGNC:6881 HGNC:6881 ENTREZ:5599 UNIPROT:P45983
DSN1 homolog, MIS12 kinetochore complex component
HUGO:DSN1 hgnc_id:HGNC:16165 HGNC:16165 ENTREZ:79980 UNIPROT:Q9H410
mitogen-activated protein kinase 9
HUGO:MAPK9 hgnc_id:HGNC:6886 HGNC:6886 ENTREZ:5601 UNIPROT:P45984
mitogen-activated protein kinase 10
HUGO:MAPK10 hgnc_id:HGNC:6872 HGNC:6872 ENTREZ:5602 UNIPROT:P53779
HUGO:MAPK8 HUGO:MAPK9 HUGO:MAPK10
JNK1
HUGO:MAPK8 HGNC:6881, ENTREZ:5599, UNIPROT:P45983
JNK2
HUGO:MAPK9 HGNC:6886, ENTREZ:5601, UNIPROT:P45984
JNK3
HUGO:MAPK10 HGNC:6872, ENTREZ:5602, UNIPROT:P53779
JNK1, mitogen-activated protein kinase 8
JNK2, mitogen-activated protein kinase 9
JNK3, mitogen-activated protein kinase 10
PRKM8
PRKM9
PRKM10
HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 GENECARDS:MAPK8 REACTOME:59293 KEGG:5599 ATLASONC:JNK1ID196 WIKI:MAPK8
HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 GENECARDS:MAPK9 REACTOME:59295 KEGG:5601 ATLASONC:JNK2ID426 WIKI:MAPK9
HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 GENECARDS:MAPK10 REACTOME:59297 KEGG:5602 ATLASONC:JNK3ID427 WIKI:MAPK10

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response   / TCR_SIGNALING 
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / CORE 
 EMT Senescence   / EMT_REGULATORS 
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair   / G2_M_CHECKPOINT 
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DNA_DAMAGE_RESPONSE 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / RCD_GENES 
 Innate Immunity   / IMMUNOSTIMULATORY_CORE_PATHWAYS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / MAPK 
 Survival   / WNT_NON_CANONICAL 

References
PMID:10849438 PMID:11371360 PMID:8205621
REACTOME:59293 KEGG:5599 ATLASONC:JNK1ID196 WIKI:MAPK8
mitogen-activated protein kinase 9
REACTOME:59295 KEGG:5601 ATLASONC:JNK2ID426 WIKI:MAPK9
mitogen-activated protein kinase 10
REACTOME:59297 KEGG:5602 ATLASONC:JNK3ID427 WIKI:MAPK10
CADCADE:TNF
CASCADE:IL1
CASCADE:PDGFB
PMID:15653932
TNF signaling activates ERK,JNK and p38 kinases in fibroblasts and induses TGFB expression
via ERK
PMID:26921338
PDGFB inhibits PEDF expression via p38 and JNK
PMID:21438496, PMID:21372320, PMID:19591900, PMID:17496919, PMID:15611655, PMID:8608010, PMID:20512932, PMID:20220133, PMID:20054826,
PMID:19616017
synonym:JNK1
synonym:JNK2
synonym:JNK3
 MACROPHAGE 
 NATURAL_KILLER 
CASCADE:IL10
CASCADE:TLR2_4
CASCADE:IL18
CASCADE:NKG2D
CASCADE:TNF
CASCADE:IFNG
PMID:18287025
JNK is localized to the centrosome.
JNK induces assosiation of Paxilin with MTOC resulted in polarization of the MTOC
and cytolytic granules, and finally exocytosis of cytolytic proteins downstream of NKG2D.
Inhibition of JNK activity by D-JNK-1, SP600125, Or JNK-1-specific siRNA blocked polarization of granzyme B,
PMID:17070508
IL-2/IL-18 prevent the down-modulation of NKG2D by TGF-beta in NK cells via the c-Jun N-terminal kinase (JNK) pathway.
PMID:10465784
ECSIT (evolutionarilyconserved signaling intermediate inToll pathways), is specific for the Toll/IL-1 pathways and is a regulator of MEKK-1 processing. Expression of wild-type ECSIT accelerates processing of MEKK-1, whereas a dominant-negative fragment of ECSIT blocks MEKK-1 processing and activation of NF-??B
ECSIT mutant also strongly inhibited MEKK-1 activation of AP-1 (probably via MAP2K4/JNK),
additionally TRAF6-induced signaling is inhibited by dominant-negative constructs of MEKK-1.
PMID:17379190
MEK4/JNK/AP-1 path way is active in mactophages downstream of TLR4,
and induces iNOS expression.
PMID:16243976
IRF4 downregulates expression of TNFa, IL12p40, IL6 probably via inhibition of NF-kB and JNK signaling pathways.
PMID:17073741
DUSP1 inhibits p38 and JNK pathways of innate innunity downstream of IL10.
PMID:9743347
IL13 inhibits JNK phosphorylation and AP1 activation (provavly via dusp1)
PMID:23681101, PMID:11477091
There are three main signaling pathways could be activated downstream of TRR4/MyD88/TAK1 signaling??: p38 (via MKK3 or MKK6), JNK (via MKK4 or MKK7) and NfkB ) IN DC all these signaling pathways are activated downstream of TLR4 and TLR2 signaling )
PMID:23508573
HMGB1 induces activation (phosphorylation) of ERK, JNK and p38 via TLR4 in macrophages.
PMID:11438547, PMID:24378531
in macrophages
Both TNFR1 and TNFR2 signaling pathways induce classical NFkB activation via IKBa degradation.
Both TNFR1 and TNFR2 signaling pathways induce JNK activation and downstrean c-jun phosphorylation.
Both TNFR1 and TNFR2 signaling pathways are needed for activation of p38 MAPK.
PMID:16713974, PMID:11579131
INFG pathway inhibits activation (phosphorylation) of ERK, JNK, p38 kinases and PI3K pathway induced by TLR. Inhibition of AKT pathway by IFNG resulted in activation of GSK3. GSK3 inhibits downstream AP-1 and CREB1 signaling and downregulates IL10 expression induced by TLR.IFNG inhibits CREB activation via p38 induced by TLR signaling

References
PMID:16713974
ad_re361:( Adaptive Immune Response  ) PMID:16713974 PMID:11438547 PMID:24378531

References
ad_re361:( Adaptive Immune Response  ) PMID:16713974 PMID:11438547 PMID:24378531
ad_re362( Adaptive Immune Response  ):
PMID:16713974
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
AP1.

References
PMID:16713974
TLR2 activates (induses phosphorylation of) ERKs, JNKs, and p38 rapidly and transiently in control macrophages.
ca_re283( Cancer Associated Fibroblasts  ):
TLR2 activates (induces phosphorylation of) ERKs, JNKs, and p38 rapidly and transiently in control macrophages.
This activation is inhibited by IFNG signaling.
PMID:11438547, PMID:24378531
Both TNFR1 and TNFR2 signaling pathways induce JNK activation and downstrean c-jun phosphorylation.

References
ca_re283( Cancer Associated Fibroblasts  ):
PMID:16713974
TLR2 activates (induces phosphorylation of) ERKs, JNKs, and p38 rapidly and transiently in control macrophages.
This activation is inhibited by IFNG signaling.
PMID:11438547, PMID:24378531
Both TNFR1 and TNFR2 signaling pathways induce JNK activation and downstrean c-jun phosphorylation.

References
mo_re297:( motility  ) PMID:29556339

References
mo_re297:( motility  ) PMID:29556339

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DNA_DAMAGE_RESPONSE 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / RCD_GENES 

References
rc_re1317( Regulated Cell Death  ):
PMID:11064451
DUSP1
PMID:11359773
DUSP16

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DNA_DAMAGE_RESPONSE 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / RCD_GENES 

References
rc_re1315( Regulated Cell Death  ):
PMID:12624093
in mouse embryonic cells, with targeted disruption of either MAP2K4 or MAP2K7, the phosphorylation pattern of JNK reveals sequential phosphorylation by these MAP2Ks
rc_re1316( Regulated Cell Death  ):
in mouse embryonic cells, with targeted disruption of either MAP2K4 or MAP2K7, the phosphorylation pattern of JNK reveals sequential phosphorylation by these MAP2KsPMID:19037093
under glucose deprivation condition, ROS are generated leading to an inactivation of JNK activity
rc_re1317( Regulated Cell Death  ):
PMID:11064451
DUSP1
PMID:11359773
DUSP16
rc_re16( Regulated Cell Death  ):
PMID:15525785 GSK3B mediated phosphorylation of Bax S163
in HEK293 human cells
in rat cerebellar granule neurons
PMID:16709574 JNK- and p38- dependent phosphrylation of BAX, most probably on T167
in HepG2 human hepatoma cell line
in LLC-PK1 porcine kidney cell line
rc_re23( Regulated Cell Death  ):
PMID:15071501
in COS cells, in HCT116 cells, phosphorylation of SFN and YWHAZ by JNK blocks their interaction with BAX
in vitro recombinant MKK7-JNK can directly phosphorylate YWHAZ
putative JNK phosphorylation sites conserved in YWHAB, YWHAE, YWHAZ, and SFN, but not in YWHAG, YWHAH nor YWHAQ
rc_re432( Regulated Cell Death  ):
PMID:12591950
in vitro, phosphorylation of BimL by JNK, mutant Bim used for identification of phospho-sites
in 293T upon UV radiations
rc_re1143( Regulated Cell Death  ):
logical:re1143_s3865_re1141=FALSE
logical:re1143_s3866_re1142=FALSE
PMID:16469705
rc_re1409( Regulated Cell Death  ):
PMID:9115213
S70 phosphorylation of BCL2 necessary for its antiapoptotic function
in NSF/N1.H7 mouse leukemia cells BCL2 mutants transfection) in response to IL-3, etoposide, or bryostatin-1, a PKC activator
PMID:9738012
suggest that PRKCA is the main PRKC BCL2 kinase in HL60 human acute myeloid leukemia cell line
PMID:10677502
ERK1/2 is a BCL2 S70 kinase in NSF/N1.H7 cells stimulated with IL-3
in vitro direct phosphorylation
PMID:11323415
JNK is a BCL2 S70 kinase in NSF/N1.H7 cells upon IL-3 withdrawal

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DNA_DAMAGE_RESPONSE 
 Regulated Cell Death   / MITOCHONDRIAL_METABOLISM 
 Regulated Cell Death   / MOMP_REGULATION 
 Regulated Cell Death   / NECROPTOSIS 
 Regulated Cell Death   / RCD_GENES 

References
PMID:16713974
TLR2 activates (induses phosphorylation of) ERKs, JNKs, and p38 rapidly and transiently in control macrophages.
in_re929( Innate Immunity  ):
TLR2 activates (induces phosphorylation of) ERKs, JNKs, and p38 rapidly and transiently in control macrophages.
This activation is inhibited by IFNG signaling.
PMID:11438547, PMID:24378531
Both TNFR1 and TNFR2 signaling pathways induce JNK activation and downstrean c-jun phosphorylation.

References
in_re929( Innate Immunity  ):
PMID:16713974
TLR2 activates (induces phosphorylation of) ERKs, JNKs, and p38 rapidly and transiently in control macrophages.
This activation is inhibited by IFNG signaling.
PMID:11438547, PMID:24378531
Both TNFR1 and TNFR2 signaling pathways induce JNK activation and downstrean c-jun phosphorylation.
in_re1149( Innate Immunity  ):
GSK3B inhitits activation (DNA binding) of AP-1 factors.
JNK is a classical activator of AP1 transcription factors.
Inhibition of JNK downregulates IL10 expression. Probably via
AP1.

References
su_mpk1_mpk1_re188( Survival  ):
P38 is able to suppress RAS-dependent JNK activation (probably through PRAK and MK2).
PMID:10978313
su_wnc1_s_wnc2_re79:( Survival  ) PMID:16648474
su_mpk1_mpk1_re156( Survival  ):
MEK4 and MEK7 can activate all JNK isoforms (by phosphorylation).
PMID:11274345
su_wnc1_s_wnc2_re82( Survival  ):
Most likely, the complex will dissociates
PMID:16648474

References
su_mpk1_mpk1_re156( Survival  ):
MEK4 and MEK7 can activate all JNK isoforms (by phosphorylation).
PMID:11274345
su_mpk1_mpk1_re169( Survival  ):
JNK could phosphorylate NFAT4 and NFAT2 inhibiting their nuclear translocation.
su_mpk1_mpk1_re183:( Survival  ) Nuclear shuttling of activated JNK is assumed similarly to ERK.
su_mpk1_mpk1_re188( Survival  ):
P38 is able to suppress RAS-dependent JNK activation (probably through PRAK and MK2).
PMID:10978313

References
su_mpk1_mpk1_re183:( Survival  ) Nuclear shuttling of activated JNK is assumed similarly to ERK.
su_mpk1_mpk1_re91( Survival  ):
The rapid and efficient phosphorylation of Elk1 by ERKs is enabled by a direct interaction between the two proteins.
ELK1 is a nuclear P38 target.
ELK1 is a nuclear JNK target.
PMID:16393692 PMID:20506250 PMID:11274345
su_mpk1_mpk1_re176( Survival  ):
ATF2 is a nuclear P38 target.
ATF2 is a nuclear JNK target.
PMID:20506250 PMID:11274345
su_mpk1_mpk1_re178( Survival  ):
JNKs are the dominant kinases responsible for stress- and TNF-activated C-JUN phosphorylation.
PMID:11274345
su_mpk1_mpk1_re180( Survival  ):
MKP-1 (DUSP1) preferentially inactivates JNK and P38.
PMID:19436832
su_mpk1_mpk1_re261( Survival  ):
JNK phosphorylates MST1 at serine 82 which leads to the enhancement of MST1 activation. The activation of MST1 phosphorylates FOXO3 at serine 207 and promotes cell death.
PMID:20028971

1. JNK*@Cytoplasm
2. JNK*@Cytoplasm
3. JNK*|​pho|​pho@Cytoplasm

1. JNK*@Cytosol
2. JNK*|​Y185_pho@Cytosol
3. JNK*|​pho|​active@Cytosol
4. JNK*|​Y185_pho|​T183_pho@Cytosol

1. JNK*@INNATE_IMMUNE_CELL_Cytosol
2. JNK*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol

1. JNK*@Nucleus
2. JNK*|​pho|​pho@Nucleus
3. JNK*|​pho|​active@Nucleus
4. JNK*|​Y185_pho|​T183_pho@Nucleus

1. JNK*@T_cell
2. JNK*|​pho|​active@T_cell

1. DUSP1:​JNK*@Nucleus

1. JNK*@T_cell → JNK*|​pho|​active@T_cell
2. JNK*@Cytosol → JNK*|​pho|​active@Cytosol
3. JNK*@Nucleus → JNK*|​pho|​active@Nucleus
4. JNK*@Nucleus → JNK1*@Nucleus
5. JNK*@Nucleus → JNK2*@Nucleus
6. JNK*@Nucleus → JNK3*@Nucleus
7. JNK*@Nucleus → JNK pathway@Cytosol
8. JNK*@INNATE_IMMUNE_CELL_Cytosol → JNK*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
9. JNK*@Nucleus → JNK*|​pho|​active@Nucleus
10. JNK1*@Cytosol → JNK*@Cytosol
11. JNK2*@Cytosol → JNK*@Cytosol
12. JNK3*@Cytosol → JNK*@Cytosol
13. JNK*@Cytosol → JNK*|​Y185_pho@Cytosol
14. JNK*@Cytosol → JNK*|​Y185_pho@Cytosol
15. JNK*|​Y185_pho|​T183_pho@Cytosol → JNK*|​Y185_pho@Cytosol
16. JNK*|​Y185_pho|​T183_pho@Cytosol → JNK*|​Y185_pho|​T183_pho@Nucleus
17. JNK*|​Y185_pho@Cytosol → JNK*@Cytosol
18. JNK*|​Y185_pho@Cytosol → JNK*|​Y185_pho|​T183_pho@Cytosol
19. JNK*|​Y185_pho|​T183_pho@Cytosol → JNK*|​Y185_pho|​T183_pho@Nucleus
20. JNK*@Cytoplasm → JNK*|​pho|​pho@Cytoplasm
21. DUSP1@Nucleus + JNK*|​pho|​pho@Nucleus → DUSP1:​JNK*@Nucleus
22. JNK*|​pho|​pho@Cytoplasm → JNK*|​pho|​pho@Nucleus
23. JNK*|​pho|​pho@Cytoplasm → JNK*@Cytoplasm
24. ASK1*@Cytoplasm → JNK*@Cytoplasm
25. JNK*@Cytoplasm → Apoptosis@Mitochondria
26. JNK*@Cytoplasm → MAPK pathway@Cytoplasm

1. AP1*@T_cell → AP1*|​pho|​active@T_cell
2. gFGF2@Cytosol → rFGF2@Cytosol
3. ETS2@Cytosol → ETS2|​pho|​active@Cytosol
4. gSERPINF1@Cytosol → rSERPINF1@Cytosol
5. CTBP*@Nucleus → CTBP*|​S422_pho@Nucleus
6. TWIST1@Nucleus → TWIST1|​S68_pho@Nucleus
7. GZMB@SECRETORY_GRANULE → GZMB@default
8. AP1*@INNATE_IMMUNE_CELL_Cytosol → AP1*|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
9. TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@INNATE_IMMUNE_CELL_Cytosol + PXN@INNATE_IMMUNE_CELL_Cytosol → PXN:​TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@INNATE_IMMUNE_CELL_Cytosol
10. JUN@Nucleus → JUN|​pho|​active@Nucleus
11. ITCH@Cytosol → ITCH|​pho@Cytosol
12. BCL2@Mitochondrial inner membrane → BCL2|​pho@Mitochondrial inner membrane
13. H2AFX|​Y142_pho@Nucleus → H2AFX|​pho|​Y142_pho@Nucleus
14. BAX@Cytosol → BAX|​S163_pho|​T167_pho@Cytosol
15. 14-3-3*@Cytosol → 14-3-3*|​pho@Cytosol
16. BCL2L11:​DYNLL1@Cytosol → BCL2L11|​S58_pho|​T56_pho|​S44_pho:​DYNLL1@Cytosol
17. CTBP*@Nucleus → CTBP*|​S422_pho@Nucleus
18. BMF:​DYNLL2@Cytosol → BMF|​pho:​DYNLL2@Cytosol
19. NFAT*@Cytoplasm → NFAT*|​pho@Cytoplasm
20. ATF2@Nucleus → ATF2|​pho@Nucleus
21. JUN@Nucleus → JUN|​pho@Nucleus
22. MST1@Nucleus → MST1|​pho@Nucleus
23. ELK1@Nucleus → ELK1|​pho@Nucleus
24. (NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm → (NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm