Identifiers
NAME:TNFRSF1A:TRADD
References
su_mpk1_mpk1_re121( Survival ):
Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins.
PMID:11274345
su_mpk1_mpk1_re122( Survival ):
TRAF proteins are recruited to the TRADD-TNFR1 complex. TRADD couples TNFR1 to TRAF2.