Protein TNFRSF1A map

Identifiers
tumor necrosis factor receptor superfamily, member 1A
HUGO:TNFRSF1A HGNC:11916 ENTREZ:7132 UNIPROT:P19438
TNFR1

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / TNF_RESPONSE  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / MAPK  map

References
PMID:28765050
Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins.
PMID:11274345

TNFRSF1A@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
HMC:DEREGULATING_CELLULAR_ENERGETICS
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / MITOCHONDRIAL_METABOLISM  map
 Regulated Cell Death  map  / TNF_RESPONSE  map

References
rc_re1148( Regulated Cell Death  map ):
PMID:12531547
PMID:11279185
CD95-mediated clustering by ceramide is prerequisite for signaling and death
PMID:26801188
rc_re1278:( Regulated Cell Death  map ) PMID:9915703

TNFRSF1A@Plasma Membrane

References
su_mpk1_mpk1_re121( Survival  map ):
Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins.
PMID:11274345

Modifications:
In compartment: Cytosol
  1. TNFRSF1A@Cytosol map
In compartment: Plasma Membrane
  1. TNFRSF1A@Plasma Membrane map
Participates in complexes:
In compartment: Cytoplasm
  1. RIPK1:​TAK1*|​pho:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm map
  2. MAP3K1|​pho:​RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm map
  3. MAP3K5|​pho:​RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm map
  4. MAP3K2_3*|​pho:​RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm map
In compartment: Cytosol
  1. BAG4:​TNFRSF1A@Cytosol map
In compartment: Plasma Membrane
  1. TNFRSF1A:​TRADD@Plasma Membrane map
  2. TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map
  3. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map
In compartment: TNFRSF1 Receptor Complex
  1. TNFRSF1A|​hm3:​TNF|​hm3@TNFRSF1 Receptor Complex map
Participates in reactions:
As Reactant or Product:
  1. TNF@Extracellular space map + TNFRSF1A@Cytosol map → map TNFRSF1A|​hm3:​TNF|​hm3@TNFRSF1 Receptor Complex map
  2. TNFRSF1A@Cytosol map + BAG4@Cytosol map → map BAG4:​TNFRSF1A@Cytosol map
  3. TNFRSF1A@Plasma Membrane map + TRADD@Cytoplasm map → map TNFRSF1A:​TRADD@Plasma Membrane map
  4. TRAF2@Cytoplasm map + TNFRSF1A:​TRADD@Plasma Membrane map → map TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map
  5. RIPK1@Cytoplasm map + TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map → map RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map
  6. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map + TAK1*@Cytoplasm map → map RIPK1:​TAK1*|​pho:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm map
  7. MAP3K1@Cytoplasm map + RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map → map MAP3K1|​pho:​RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm map
  8. MAP3K2_3*@Cytoplasm map + RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map → map MAP3K2_3*|​pho:​RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm map
  9. TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map → map ROS@Cytoplasm map
  10. RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Plasma Membrane map + MAP3K5@Cytoplasm map → map MAP3K5|​pho:​RIPK1:​TNFRSF1A:​TRADD:​TRAF2@Cytoplasm map
As Catalyser:
  1. TRADD@Cytosol map → map TRADD@TNFRSF1 Receptor Complex map
  2. TRAF2@Cytosol map → map TRAF2@TNFRSF1 Receptor Complex map
  3. DAB2IP@Cytosol map → map DAB2IP@TNFRSF1 Receptor Complex map
  4. Ceramide@Cytosol map → map rc_s5993
  5. NSMAF|​pho@Cytosol map → map NSMAF@Cytosol map
  6. NSMAF@Cytosol map + SMPD1@Cytosol map → map NSMAF:​SMPD1@Cytosol map
  7. MAP2K4@Cytoplasm map → map MAP2K4|​pho|​pho@Cytoplasm map
  8. MAP2K3@Cytoplasm map → map MAP2K3|​pho|​pho@Cytoplasm map
  9. MAP2K7@Cytoplasm map → map MAP2K7|​pho|​pho@Cytoplasm map
  10. MAP2K6@Cytoplasm map → map MAP2K6|​pho|​pho@Cytoplasm map
  11. MEK*@Cytoplasm map → map MEK*|​pho|​pho@Cytoplasm map