Protein CXCR1 map

Identifiers
HUGO:CXCR1

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / SENESCENCE  map
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity  map  / RECRUITMENT_OF_IMMUNE_CELLS  map
 Innate Immunity  map  / MARKERS_NEUTROPHIL  map

References
PMID:17533374
HIF-1 and NF-kappaB upregulates CXCR1 and CXCR2 expression
PMID:26548401
IL-8 exerts its effect by binding to the IL-8Rs, which are
two heterotrimeric G protein-coupled receptors, CXCR1 and CXCR2.
 NEUTROPHIL  map
CASCADE:IL8
PMID:18633355
The surface markers of myeloid cells
PMID:21328342, PMID:18980965
Neutrophil recruitment into tumors appears to be dependent on chemokines that bind to CXCR1 and CXCR2 expressed by neutrophils,
downstream of IL8.

CXCR1@Cytosol

References
em_re1568( EMT Senescence  map ):
PMID:17533374
HIF-1 and NF-kappaB upregulates CXCR1 and CXCR2 expression

Modifications:
In compartment: Cytosol
  1. CXCR1@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CXCR1@INNATE_IMMUNE_CELL_Membrane map
In compartment: MARKERS_NEUTROPHIL
  1. CXCR1@MARKERS_NEUTROPHIL map
Participates in complexes:
In compartment: Cytosol
  1. CXCL8:​CXCR1@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Membrane
  1. CXCR1:​IL8*@INNATE_IMMUNE_CELL_Membrane map
Participates in reactions:
As Reactant or Product:
  1. NF-_kappa_B pathway@Cytosol map → map CXCR1@Cytosol map
  2. rCXCR1@Nucleus map → map CXCR1@Cytosol map
  3. CXCR1@Cytosol map + CXCL8@Extracellular space map → map CXCL8:​CXCR1@Cytosol map
  4. IL8*@default map + CXCR1@INNATE_IMMUNE_CELL_Membrane map → map CXCR1:​IL8*@INNATE_IMMUNE_CELL_Membrane map
  5. CXCR1:​IL8*@INNATE_IMMUNE_CELL_Membrane map → map RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol map
As Catalyser: