Protein FAS map

Identifiers
Fas cell surface death receptor
HUGO:FAS HGNC:11920 ENTREZ:355 UNIPROT:P25445

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / SENESCENCE  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / FAS_RESPONSE  map
 Regulated Cell Death  map  / RCD_GENES  map

References
PMID:16940415
PMID:9759866
TCDD regulates Fas and FasL promoters through DRE and/or NF-kappaB motifs via AhR.
PMID:12724420
PMID:23069999
Fas is a death receptor, upon ligation of his ligand, it trigger apoptosis
PMID:19597341
PMID:16498403

FAS@Cytosol

References
em_re1542( EMT Senescence  map ):
PMID??:9759866
TCDD regulates Fas and FasL promoters through DRE and/or NF-kappaB motifs via AhR.

FAS@Vesicle

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / FAS_RESPONSE  map
 Regulated Cell Death  map  / RCD_GENES  map

References
rc_re1671( Regulated Cell Death  map ):
FAP-1 association with Fas (Apo-1) inhibits Fas expression on the cell surface
PMID:12724420

Modifications:
In compartment: Cytosol
  1. FAS@Cytosol map
In compartment: Vesicle
  1. FAS@Vesicle map
Participates in complexes:
In compartment: Cytosol
  1. FAS:​FASLG@Cytosol map
  2. FASLG:​FAS|​pal@Cytosol map
In compartment: Endosome
  1. Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map
  2. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map
  3. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map
Participates in reactions:
As Reactant or Product:
  1. NF-_kappa_B pathway@Cytosol map → map FAS@Cytosol map
  2. FAS:​FASLG@Cytosol map → map FAS@Vesicle map
  3. FAS@Cytosol map + FASLG@Extracellular space map → map FAS:​FASLG@Cytosol map
  4. FASLG:​FAS|​pal@Cytosol map + Caspase8,10*:​FLASH*@Cytosol map + FAF1@Cytosol map + FADD@Cytosol map + DAXX@Cytosol map + RIPK1@Cytosol map → map Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map
  5. Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map → map CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map
  6. FAS:​FASLG@Cytosol map → map FASLG:​FAS|​pal@Cytosol map
  7. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map → map ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map
  8. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map → map RIPK1|​S161_pho:​RIPK3|​S199_pho@Cytosol map
  9. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map → map ASK1*@Cytosol map
  10. CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map → map Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map
  11. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map → map CFLAR:​Caspase8,10*|​ubi:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​MLKL:​RIPK1|​emp|​S161_pho:​RIPK3|​S199_pho@Endosome map
  12. ASK1*:​CFLAR:​Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1|​emp|​K377_ubi:​TRAF2@Endosome map → map Caspase8*|​ubi:​FLASH*@Cytosol map
  13. Caspase8,10*|​ubi:​DAXX:​FADD:​FAF1:​FASLG:​FAS|​pal:​FLASH*:​RIPK1@Endosome map → map rc_s6308
  14. rFAS@Nucleus map → map FAS@Cytosol map
As Catalyser: