Identifiers
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / CELL_CELL_ADHESIONS 
 EMT Senescence   / TIGHT_JUNCTIONS 
 EMT Senescence   / CYTOSKELETON_POLARITY 

References
PMID:21667018
PMID:16001073
Rac1B is an alternatively spliced form of Rac1 gene.
Rac1B does not lead to lamellipodia formation, or the activation of PAK1, AKT1, or c-Jun-NH2- kinase activities.
However, Rac1B retains the ability to stimulate the NF-kappa-B pathway.

References
em_emtc_emtc_re1229( EMT Senescence  ):
PMID:21667018
Rac1B is an alternatively spliced form of Rac1 gene.
Rac1B does not lead to lamellipodia formation, or the activation of PAK1, AKT1, or c-Jun-NH2- kinase activities.
However, Rac1B retains the ability to stimulate the NF-kappa-B pathway.
PMID:16001073
MMP3 can induce the expression of RACB1.
RACB1 increases the cellular levels of ROS, causing an upregulation of Snail and induction of EMT.
em_re1561( EMT Senescence  ):

References
em_emtc_emtc_re1235( EMT Senescence  ):
PMID:16001073
RAC1B increases the cellular level of ROS, causing an upregulation of Snail and induction of EMT

1. RAC1B*@Cytosol

1. RAC1B*@Nucleus

1. rRAC1@Nucleus → RAC1B*@Cytosol
2. RAC1B*@Cytosol → RAC1B*@Nucleus
3. RAC1B*@Nucleus → ROS@Nucleus
4. RAC1B*@Cytosol → NF-_kappa_B pathway@Cytosol