Identifiers
itwist homolog 1 (Drosophila)
HUGO:TWIST1 HGNC:12428, ENTREZ:7291, GENECARDS:GC07M019121
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
References
em_emtc_emtc_re6( EMT Senescence ):
PMID:21883379
PMID:18297062
TWIST is a downstream target of HIF-1
Hypoxia or HIF-1 induces EMT through the direct activation of TWIST expression
PMID:19412634
Twist is a target of Snail1
PMID:22945800
PMID:21317430
Expression of Twist1 and Snail1 are mutually dependent
Knock-down of Snail1 downregulates Twist1 protein and mRNA
Knock- down of Twist1 interferes with TGFb-mediated induction of Snail1.
PMID:22006115
Alternatively, it has also been reported that Snail1 transcriptionally represses Twist1
PMID:16831886
PMID:18832382
HMGA2 directly binds to the SNAIL1 promoter and acts as a transcriptional regulator of SNAIL1 expression.
HMGA2 cooperates with SMAD3 and SMAD4 to execute a dramatic super-induction of the SNAIL1 promoter.
Same results were obtained with SNAI2, ZEB1, ZEB2 and TWIST1
HMGA2 cooperates with TGFB1 signaling to represse ID2 transcriptomal expression
PMID:17403902
Twist1 is a direct downstream target of NKFB.