Reaction transcription em_emtc_emtc_re63 map

gMMP3@Nucleus map → rMMP3@Nucleus map

Reaction regulators:
Physical_stimulation
  1. ETS1@Nucleus map
  2. NF-_kappa_B pathway@Cytosol map


References
PMID:10048576
The gene expressions of MMP-1, MMP-3, and MMP-9 and gelatinolytic activity of MMP-9 were significantly increased in high ETS-1 expression cells.
Low ETS-1 expression cells could not spread on a vitronectin substratum, and the phosphorylation of focal adhesion kinase was markedly impaired because of the reduced expression of integrin b3
PMID:15003528
NF-kappaB binds to a polymorphic repressor element in the MMP-3 promoter.