Identifiers
HUGO:CXCR2

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / SENESCENCE 
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity   / MARKERS_NEUTROPHIL 
 Innate Immunity   / RECRUITMENT_OF_IMMUNE_CELLS 

References
PMID:18555777
CXCR2 (IL8RB), binds IL8 and induces a self-amplifying secretory network in which CXCR2-binding chemokines reinforce senescence_induced growth arrest
PMID:17533374
HIF-1 and NF-kappaB upregulates CXCR1 and CXCR2 expression
PMID:23869868
Chemokine receptor CXCR2 is transactivated by p53 and induces p38-mediated cellular senescence
 NEUTROPHIL 
CASCADE:IL8
PMID:18633355
The surface markers of myeloid cells
PMID:21328342, PMID:18980965
Neutrophil recruitment into tumors appears to be dependent on chemokines that bind to CXCR1 and CXCR2 expressed by neutrophils,
downstream of IL8.

References
em_re1552( EMT Senescence  ):
PMID:17533374
HIF-1 and NF-kappaB upregulates CXCR1 and CXCR2 expression
em_re1574( EMT Senescence  ):
PMID:23869868
Chemokine receptor CXCR2 is transactivated by p53
em_re1583( EMT Senescence  ):
Chemokine receptor CXCR2 is transactivated by p53 and induces p38-mediated cellular senescence
PMID:24954210
PMID:17254968
MAPK3 and MAPK6 induces p38 which induces p16 and p53

1. CXCR2@Cytosol

1. CXCR2@INNATE_IMMUNE_CELL_Membrane

1. CXCR2@MARKERS_NEUTROPHIL

1. CXCL8:​CXCR2@Cytosol

1. CXCR2:​IL8*@INNATE_IMMUNE_CELL_Membrane

1. NF-_kappa_B pathway@Cytosol → CXCR2@Cytosol
2. CXCL8@Extracellular space + CXCR2@Cytosol → CXCL8:​CXCR2@Cytosol
3. rCXCR2@Nucleus → CXCR2@Cytosol
4. IL8*@default + CXCR2@INNATE_IMMUNE_CELL_Membrane → CXCR2:​IL8*@INNATE_IMMUNE_CELL_Membrane
5. CXCR2:​IL8*@INNATE_IMMUNE_CELL_Membrane → RECRUITMENT_OF_IMMUNE_CELLS@INNATE_IMMUNE_CELL_Cytosol

1. gMAPK14@Nucleus → rMAPK14@Nucleus