Identifiers
v-rel reticuloendotheliosis viral oncogene homolog A (avian)
HUGO:RELA HGNC:9955 ENTREZ:5970 UNIPROT:Q04206
Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
EMT Senescence / EMT_REGULATORS
EMT Senescence / SENESCENCE
References
PMID:19411070
TNFa dramatically enhanced the protein stabilization of Snail1 through NF-kB mediated CSN2 induction.
CSN2 induces Snail stabilization by inhibiting its ubiquitination
PMID:17563753
References
em_emtc_emtc_re1218( EMT Senescence ):
PMID:19411070
Activation of NFKB pathway by TNFa
TNFa dramatically enhanced the protein stabilization of Snail1 through NF-kB mediated CSN2 induction.
em_emtc_emtc_re1( EMT Senescence ):
PMID:20731704
PMID:21317430
In NMuMG cells treated with TGFB1 Snail1 RNA and protein are induced 1 h after addition of the cytokine preceding Zeb1 up-regulation that requires 6???8 h.
Zeb1 gene expression is caused by increased RNA levels but also by enhanced protein stability and is markedly dependent on Snail1 because depletion of this protein prevents Zeb1 protein and RNA up-regulation
PMID:22406545
TGFB can activate both SNAI1 and SNAI2 and thus promote EMT via both SMAD-dependent and -independent pathways
PMID:16617148
Negative feedback by SNAI1 itself
PMID:17671186
KLF8 directly bound to the promotor of Snail and repressed Snail expression
PMID:17563753
Snail promoter is regulated positively by NFkB_p65
PMID:16831886
PMID:18832382
HMGA2 directly binds to the SNAIL1 promoter and acts as a transcriptional regulator of SNAIL1 expression.
HMGA2 cooperates with SMAD3 and SMAD4 to execute a dramatic super-induction of the SNAIL1 promoter.
Same results were obtained with SNAI2, ZEB1, ZEB2 and TWIST1
HMGA2 cooperates with TGFB1 signaling to represse ID2 transcriptomal expression