Identifiers
X-linked inhibitor of apoptosis
HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170
API3 "baculoviral IAP repeat-containing 4" BIRC4
HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 GENECARDS:XIAP REACTOME:50850 KEGG:331 ATLASONC:GC_XIAP WIKI:XIAP

Maps_Modules
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence   / EMT_REGULATORS 
 EMT Senescence   / SENESCENCE 
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DEPENDANCE_RECEPTORS 
 Regulated Cell Death   / TNF_RESPONSE 
 Regulated Cell Death   / ER_STRESS 
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival   / WNT_CANONICAL 

References
PMID:17435549
Bile salts induce resistance to apoptosis through NF-kappaB-mediated XIAP expression.
PMID:22733138
XIAP (X-linked IAP, BIRC4) is a critical barrier to apoptosis induction in cancer cells because of its robust affinity to bind and inhibit initiator caspase-9 and effector caspases -3 and -7
PMID:26587781
PMID:23070005

References
em_re1566( EMT Senescence  ):
PMID:22733138
XIAP (X-linked IAP, BIRC4) is a critical barrier to apoptosis induction in cancer cells because of its robust affinity to bind and inhibit initiator caspase-9 and effector caspases -3 and -7

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DEPENDANCE_RECEPTORS 
 Regulated Cell Death   / TNF_RESPONSE 

References
rc_re489:( Regulated Cell Death  ) PMID:14645242
rc_re492:( Regulated Cell Death  ) reactionType:is.a

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DEPENDANCE_RECEPTORS 
 Regulated Cell Death   / TNF_RESPONSE 

References
rc_re645( Regulated Cell Death  ):
PMID:14645242
autoubiquitinylation

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DEPENDANCE_RECEPTORS 
 Regulated Cell Death   / TNF_RESPONSE 

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / APOPTOSIS 
 Regulated Cell Death   / STARVATION_AUTOPHAGY 
 Regulated Cell Death   / CASPASES 
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DEPENDANCE_RECEPTORS 
 Regulated Cell Death   / TNF_RESPONSE 

References
s_wca3_re39( Survival  ):
Its suggested that XIAP constitutively ubiquitinate TLE
PMID:22304967
s_wca3_re40( Survival  ):
Not sure if ubiquitination by XIAP is necessary for replacement of TLE by b-catenin upon canonical WNT signaling
su_wca1_s_wca3_re40( Survival  ):

1. XIAP@Cytosol
2. XIAP|​ubi@Cytosol
3. XIAP|​S87_pho@Cytosol
4. XIAP|​S87_unk@Cytosol

1. XIAP@Nucleus

1. XIAP@TNFRSF1 Receptor Complex

1. XAF1:​XIAP@Cytosol
2. NRAGE*:​XIAP@Cytosol
3. SEPT4:​XIAP|​S87_unk@Cytosol
4. DIABLO:​XIAP|​S87_unk@Cytosol
5. Caspase3*:​XIAP|​S87_unk@Cytosol
6. Caspase7*:​XIAP|​S87_unk@Cytosol
7. XIAP|​S87_unk:​cleaved~GSPT1*@Cytosol
8. XIAP|​S87_unk:​cleaved~Caspase9*@Cytosol
9. Caspase9*|​S196_unk|​T125_unk|​S144_unk|​Y153_unk:​XIAP|​S87_unk|​hm2@Cytosol

1. XAF1:​XIAP|​S87_unk@Nucleus

1. TAB*:​TAK1*:​XIAP@TNFRSF1 Receptor Complex

1. NF-_kappa_B pathway@Cytosol → XIAP@Cytosol
2. XIAP@Cytosol → Apoptosis@Cytosol
3. XAF1@Cytosol + XIAP@Cytosol → XAF1:​XIAP@Cytosol
4. XIAP|​S87_unk@Cytosol + Caspase3*@Cytosol → Caspase3*:​XIAP|​S87_unk@Cytosol
5. XIAP|​S87_unk@Cytosol + Caspase7*@Cytosol → Caspase7*:​XIAP|​S87_unk@Cytosol
6. XIAP@TNFRSF1 Receptor Complex + TAK1*@TNFRSF1 Receptor Complex + TAB*@TNFRSF1 Receptor Complex → TAB*:​TAK1*:​XIAP@TNFRSF1 Receptor Complex
7. XIAP@Cytosol + NRAGE*:​UNC5A@Cytosol → NRAGE*:​XIAP@Cytosol + UNC5A@Cytosol
8. NRAGE*@Cytosol + XIAP@Cytosol → NRAGE*:​XIAP@Cytosol
9. rXIAP@Nucleus → XIAP@Cytosol
10. XIAP@Cytosol → degraded
11. XIAP@Cytosol → Apoptosis@Cytosol
12. rXIAP@Nucleus → XIAP@Cytosol
13. XIAP@Cytosol → XIAP|​S87_pho@Cytosol
14. XIAP@Cytosol → XIAP|​S87_unk@Cytosol
15. XIAP|​S87_pho@Cytosol → XIAP|​S87_unk@Cytosol
16. XIAP|​S87_unk@Cytosol + Caspase9*|​S196_unk|​T125_unk|​S144_unk|​Y153_unk@Cytosol → Caspase9*|​S196_unk|​T125_unk|​S144_unk|​Y153_unk:​XIAP|​S87_unk|​hm2@Cytosol
17. XIAP@Cytosol → XIAP|​ubi@Cytosol
18. XIAP|​ubi@Cytosol → degraded
19. XIAP|​S87_unk@Cytosol → CAPN2:​Ca2+_@Cytosol
20. XIAP|​S87_unk@Cytosol + XAF1@Nucleus → XAF1:​XIAP|​S87_unk@Nucleus
21. XIAP|​S87_unk@Cytosol + SEPT4@Cytosol → SEPT4:​XIAP|​S87_unk@Cytosol
22. XIAP|​S87_unk@Cytosol + cleaved~GSPT1*@Cytosol → XIAP|​S87_unk:​cleaved~GSPT1*@Cytosol
23. XIAP|​S87_unk@Cytosol + DIABLO@Cytosol → DIABLO:​XIAP|​S87_unk@Cytosol
24. XIAP|​S87_unk@Cytosol + cleaved~Caspase9*@Cytosol → XIAP|​S87_unk:​cleaved~Caspase9*@Cytosol

1. cleaved~AIFM1*@Cytosol → cleaved~AIFM1*|​ubi@Cytosol
2. TLE*@Nucleus → TLE*|​ubi@Nucleus
3. HDAC1_2*:​LEF_TCF*:​TLE*:​WRE*@Nucleus → HDAC1_2*:​LEF_TCF*:​TLE*|​ubi:​WRE*@Nucleus