Protein NGF map

Identifiers
nerve growth factor
HUGO:NGF hgnc_id:HGNC:7808 HGNC:7808 ENTREZ:4803 UNIPROT:P01138
nerve growth factor (beta polypeptide)
HUGO:NGF HGNC:7808 ENTREZ:4803 UNIPROT:P01138
HUGO:NGF

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / GROWTH_FACTORS_PRODUCTION  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map
 Innate Immunity  map  / TUMOR_GROWTH  map

References
PMID:25071162
PMID:22465479
 MAST_CELL  map
PMID:15099563
Mast cells produce heparin, interleukin-8 (IL-8) and vascular
endothelial cell growth factor (VEGF), which induce
neovascularization, histamine, which is an immunosuppressant,
mitogenic factors, such as platelet-derived
growth factor (PDGF), nerve GF (NGF), stem-cell factor
(SCF), and proteases, which disrupt the surrounding
matrix and facilitate metastases.
PMID:17764704
NGF is angiogenic factor

NGF@Extracellular space

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map

References
rc_re1713:( Regulated Cell Death  map ) PMID:15721744

Modifications:
In compartment: Cytosol
  1. NGF@Cytosol map
In compartment: Extracellular space
  1. NGF@Extracellular space map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. NGF@INNATE_IMMUNE_CELL_Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. NGF:​TrkA*@Cytosol map
  2. IRS1|​pho:​NGF:​PI3K*:​TrkA*@Cytosol map
  3. NADE*:​NGF:​NGFR:​NRAGE*:​NRIF*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. NGF@Cytosol map → map GROWTH_FACTORS_PRODUCTION@default map
  2. NGF@INNATE_IMMUNE_CELL_Cytosol map → map ANGIOGENESIS@default map
  3. IRS1@Cytosol map + NGF:​TrkA*@Cytosol map + PI3K*@Cytosol map → map IRS1|​pho:​NGF:​PI3K*:​TrkA*@Cytosol map
  4. NGF@Extracellular space map + TrkA*@Cytosol map → map NGF:​TrkA*@Cytosol map
  5. NGF@Extracellular space map + NGFR@Cytosol map + NRAGE*@Cytosol map + NRIF*@Cytosol map + NADE*@Cytosol map → map NADE*:​NGF:​NGFR:​NRAGE*:​NRIF*@Cytosol map
  6. NADE*:​NGF:​NGFR:​NRAGE*:​NRIF*@Cytosol map → map NGFR-ICD*:​NRIF*:​TRAF6@Cytosol map
As Catalyser:
  1. Sphingomyelin@Cytosol map + H2O@Cytosol map → map Ceramide@Cytosol map + Choline Phosphate@Cytosol map
  2. PIP2*@Cytosol map → map PIP3*@Cytosol map
  3. NRAGE*@Cytosol map + XIAP@Cytosol map → map NRAGE*:​XIAP@Cytosol map
  4. AATF@Cytosol map → map degraded
  5. NRAGE*@Cytosol map + GEF*@Cytosol map → map GEF*:​NRAGE*@Cytosol map
  6. Caspase3*@Cytosol map → map cleaved~Caspase3*@Cytosol map
  7. Caspase2*@Cytosol map → map cleaved Caspase2*@Cytosol map