Complex IRS1:NGF:PI3K*:TrkA* map
Complex composition:

  1. IRS1 map
  2. PI3K* map
  3. NGF map
  4. TrkA* map

IRS1|​pho:​NGF:​PI3K*:​TrkA*@Cytosol

Identifiers
NAME:IRS1:NGF:PI3K*:TrkA*

References
PMID:17604717
The lack of NGF suppresses the survival signals controlled by PI3K-Akt, finally leading to a de-repression of the pro-apoptotic Bad; on the other hand, the loss of the survival signals is associated with JNK-mediated transcriptional activation of other pro-apoptotic inducers such as DP5, Bim and Puma.
rc_re1705( Regulated Cell Death  map ):
PMID:22465479
PI3K phosphorylates phosphatidylinositol-4,5-bisphosphate (PIP2) to generate phosphatidylinositol-3,4,5-trisphosphate (PIP3), in a reaction that can be reversed by the PIP3 phosphatase PTEN

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. IRS1|​pho:​NGF:​PI3K*:​TrkA*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. IRS1@Cytosol map + NGF:​TrkA*@Cytosol map + PI3K*@Cytosol map → map IRS1|​pho:​NGF:​PI3K*:​TrkA*@Cytosol map
As Catalyser:
  1. PIP2*@Cytosol map → map PIP3*@Cytosol map