Identifiers
melanoma antigen family D, 1
HUGO:MAGED1 HGNC:6813 ENTREZ:9500 UNIPROT:Q9Y5V3

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DEPENDANCE_RECEPTORS 

References
PMID:12376548
NRAGE induces caspase activation and cell death through a JNK-dependent mitochondrial pathway
PMID:15721744
PMID:11546791
PMID:17488777
NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death.
PMID:23314527

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death   / DEATH_RECEPTOR_PATHWAYS 
 Regulated Cell Death   / DEPENDANCE_RECEPTORS 

References
rc_re1719( Regulated Cell Death  ):
PMID:11756498
Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis

1. NRAGE*@Cytosol

1. GEF*:​NRAGE*@Cytosol
2. NRAGE*:​XIAP@Cytosol
3. NRAGE*:​UNC5A@Cytosol
4. NADE*:​NGF:​NGFR:​NRAGE*:​NRIF*@Cytosol

1. NTN1:​UNC5A@Cytosol → NRAGE*:​UNC5A@Cytosol + NTN1@Extracellular space
2. XIAP@Cytosol + NRAGE*:​UNC5A@Cytosol → NRAGE*:​XIAP@Cytosol + UNC5A@Cytosol
3. NGF@Extracellular space + NGFR@Cytosol + NRAGE*@Cytosol + NRIF*@Cytosol + NADE*@Cytosol → NADE*:​NGF:​NGFR:​NRAGE*:​NRIF*@Cytosol
4. NRAGE*@Cytosol + XIAP@Cytosol → NRAGE*:​XIAP@Cytosol
5. NRAGE*@Cytosol + GEF*@Cytosol → GEF*:​NRAGE*@Cytosol
6. NADE*:​NGF:​NGFR:​NRAGE*:​NRIF*@Cytosol → NGFR-ICD*:​NRIF*:​TRAF6@Cytosol

1. Sphingomyelin@Cytosol + H2O@Cytosol → Ceramide@Cytosol + Choline Phosphate@Cytosol
2. NRAGE*@Cytosol + XIAP@Cytosol → NRAGE*:​XIAP@Cytosol
3. rc_s5973 + GTP@Cytosol → rc_s5974 + GDP@Cytosol
4. AATF@Cytosol → degraded
5. NRAGE*@Cytosol + GEF*@Cytosol → GEF*:​NRAGE*@Cytosol
6. Caspase3*@Cytosol → cleaved~Caspase3*@Cytosol
7. Caspase2*@Cytosol → cleaved Caspase2*@Cytosol