Identifiers
insulin receptor substrate 1
HUGO:IRS1 hgnc_id:HGNC:6125 HGNC:6125 ENTREZ:3667 UNIPROT:P35568
HUGO:IRS1 HGNC:6125 ENTREZ:3667 UNIPROT:P35568
Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
Cancer Associated Fibroblasts / GROWTH_FACTORS_SIGNALING_PATHWAYS
EMT Senescence / EMT_REGULATORS
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / DEATH_RECEPTOR_PATHWAYS
Regulated Cell Death / DEPENDANCE_RECEPTORS
References
GASCADE:IGF1R
PMID:8621421
Grb2- and Shc-SH2 domain binding to phosphopeptides from rat IRS-1
PMID:12175651; PMID:10086337
Upon IGF-IR autophosphorylation the protein Shc is recruited to the receptor and becomes phosphorylated on tyrosine residues.36 Activated Shc then binds the adaptor Grb2 in an IRS-1-independent manner, leading to activation of the Ras-ERK pathway.36 This pathway of IGF-IR signaling has been most closely associated with cell differentiation and migration, but in some cases also can regulate the machinery of apoptosis, for example, in detachment-induced death, or anoikis, in fibroblasts.
Upon IGF stimulation, the activated IGF1R recruits and directly phosphorylates IRS1, leading to both PI3K and (GRB2/SOS/HRas) pathways activation
PMID:12175651
PMID:10826997
PMID:12767520
PMID:19030972
PMID:16931767
PMID:21540285
PMID:12444011
PMID:17604717
PMID:24036369
PMID:22465479
Activated receptor tyrosine kinases (RTKs) activate class I phosphatidylinositol 3-kinase (PI3K) through direct binding or through tyrosine phosphorylation of scaffolding adaptors, such as IRS1, which then bind and activate PI3K
References
em_emtc_emtc_re1609( EMT Senescence ):
Upon IGF stimulation, the activated IGF1R recruits and directly phosphorylates IRS1, leading to both PI3K and (GRB2/SOS/HRas) pathways activation
PMID:12175651
PMID:10826997
PMID:12767520
PMID:19030972
PMID:16931767
PMID:21540285
PMID:12444011