1. NADE*
2. NRIF*
3. NRAGE*
4. NGFR
5. NGF

Identifiers
NAME:NADE*:NGF:NGFR:NRAGE*:NRIF*

References
PMID:15548667
PMID:15721744
p75NTR interactors NT-receptor interacting factor (NRIF), NT-associated cell death executor (NADE), NT-receptor-interacting MAGE homolog (NRAGE) and TNF receptor-associated factors (TRAFs) have, alone or in combination, been shown to activate JNK and promote p75NTR-dependent apoptosis
PMID:14673001
Apoptosis induced by p75NTR overexpression requires Jun kinase-dependent phosphorylation of Bad.
rc_re1550( Regulated Cell Death  ):
PMID:12387875
PMID:9841888
rc_re1714:( Regulated Cell Death  ) PMID:12376548
rc_re1718( Regulated Cell Death  ):
PMID:17488777
NRAGE associates with the anti-apoptotic factor Che-1 and regulates its degradation to induce cell death.
rc_re1719( Regulated Cell Death  ):
PMID:11756498
Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis
rc_re1720( Regulated Cell Death  ):
PMID:16252010
NRIF is a substrate for TRAF6-mediated K63 polyubiquitination and that this modification is necessary for its nuclear translocation.
PMID:16630834
rc_re1724:( Regulated Cell Death  ) PMID:10764727

1. NADE*:​NGF:​NGFR:​NRAGE*:​NRIF*@Cytosol

1. NGF@Extracellular space + NGFR@Cytosol + NRAGE*@Cytosol + NRIF*@Cytosol + NADE*@Cytosol → NADE*:​NGF:​NGFR:​NRAGE*:​NRIF*@Cytosol
2. NADE*:​NGF:​NGFR:​NRAGE*:​NRIF*@Cytosol → NGFR-ICD*:​NRIF*:​TRAF6@Cytosol

1. Sphingomyelin@Cytosol + H2O@Cytosol → Ceramide@Cytosol + Choline Phosphate@Cytosol
2. NRAGE*@Cytosol + XIAP@Cytosol → NRAGE*:​XIAP@Cytosol
3. AATF@Cytosol → degraded
4. NRAGE*@Cytosol + GEF*@Cytosol → GEF*:​NRAGE*@Cytosol
5. Caspase3*@Cytosol → cleaved~Caspase3*@Cytosol
6. Caspase2*@Cytosol → cleaved Caspase2*@Cytosol