Catalysis

1. IRS1|​pho:​NGF:​PI3K*:​TrkA*@Cytosol

References
PMID:22465479
PI3K phosphorylates phosphatidylinositol-4,5-bisphosphate (PIP2) to generate phosphatidylinositol-3,4,5-trisphosphate (PIP3), in a reaction that can be reversed by the PIP3 phosphatase PTEN