Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response   / TCR_SIGNALING 

References
PMID:12040186 PMID:9438848 PMID:12670391 PMID:11526404

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts   / CORE 

References
CASCADE:PDGF
PMID:12040186
The activated PI3K converts the plasma membrane lipid phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] to phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
PMID:11696562
Integrin-linked kinase (ILK) is a binding partner of the integrin 1 and 3 subunits and is involved in the signal transduction from integrin receptors
The activity is stimulated in a phosphatidylinositol (PI) 3-kinase???dependent manner and likely involves binding of the phosphoinositide phospholipid product of PI 3-kinase, PI 3,4,5-triphosphate, to the PH-like domain of ILK
ILK has been shown recently to directly phosphorylate proteins such as PKB (PKB/Akt) on ser 473.
PMID:27111285
ILK???PI3K/AKT pathway participates in cutaneous wound contraction by regulating fibroblast migration and differentiation to myofibroblast
ca_re463( Cancer Associated Fibroblasts  ):
PMID:??12094222??
VAV proteins activate RAC1 via induction of GDP/GTP exchange.

Identifiers
CHEBI:16618

References
PMID:17604717
PMID:23301705
PMID:22166994
rc_re1765:( Regulated Cell Death  ) PMID:23725295
rc_re1763:( Regulated Cell Death  ) PMID:18586673

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity   / IMMUNOSTIMULATORY_CORE_PATHWAYS 

References
 NATURAL_KILLER 
CASCADE:NKP80
CASCADE:NKG2D
CASCADE:IL4
CASCADE:NKP46
CASCADE:Fc_gamma_RIII
CASCADE:IL15
CASCADE:CSF2
CASCADE:IFNG
PMID:11062502, PMID:11385609, PMID:11907067, PMID:15536084
Nkp46 controls NK cytolitic activity via PI3K /RAC1/PAK1/MEK??/ERK pathway, probably throught SYK
PMID:11777960
ULBP2 through NKG2D induces SCF2 (GM-CSF), CLL4 (MIP1B) and IFNG secretion via PI3K pathway
PMID:12040186
The activated PI3K converts the plasma membrane lipid phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] to phosphatidylinositol-3,4,5-trisphosphate [PI(3,4,5)P3].
PMID:9438848
PI3K product phosphatidylinositol-3,4,5-trisphosphate enhanced phosphorylation and activation of Vav proteins
PMID:12393695
SHIP1 inhinits NK cells activation via bloking of PI3K pathway. It hydrolyzes the 5???-phosphate of PI3,4,5P3l eading to its conversion to PI3,4P2.
PMID:20363967, PMID:16204085
Src homology 2-containing inositol 5'-phosphatase 1 negatively regulates IFN-gamma production by natural killer cells stimulated with antibody-coated tumor cells and interleukin-12, probably via inhibition of PI3K pathway and downstream ERK signaling.

1. PIP3*@Autopagosome

1. PIP3*@Cytosol

1. PIP3*@INNATE_IMMUNE_CELL_Cytosol

1. PIP3*@T_cell

1. LC3*:​PIP3*@Autopagosome
2. PIP3*:​WIP*@Autopagosome
3. ATG2*:​PIP3*@Autopagosome
4. DCFP1*:​PIP3*@Autopagosome

1. PDPK1:​PIP3*@Cytosol

1. PDPK1:​PIP3*@INNATE_IMMUNE_CELL_Cytosol

1. ITK:​PIP3*@T_cell
2. PIP3*:​TEC@T_cell
3. PIP3*:​TXK@T_cell
4. PDPK1:​PIP3*@T_cell
5. PIP3*:​TXK|​pho@T_cell
6. (ITK|​pho:​PIP3*)|​active@T_cell
7. (PIP3*:​TEC|​pho)|​active@T_cell

1. PDPK1:​PIP3*@cSMAC

1. PIP2*@T_cell → PIP3*@T_cell
2. PDPK1@T_cell + PIP3*@T_cell → PDPK1:​PIP3*@T_cell
3. PIP3*@T_cell → PIP2*@T_cell
4. ITK:​PIP3*@T_cell → (ITK|​pho:​PIP3*)|​active@T_cell
5. PDPK1:​PIP3*@T_cell → PDPK1:​PIP3*@cSMAC
6. TEC@T_cell + PIP3*@T_cell → PIP3*:​TEC@T_cell
7. PIP3*:​TEC@T_cell → (PIP3*:​TEC|​pho)|​active@T_cell
8. PIP3*@T_cell + ITK@T_cell → ITK:​PIP3*@T_cell
9. PIP3*:​TXK@T_cell → PIP3*:​TXK|​pho@T_cell
10. PIP3*@T_cell + TXK@T_cell → PIP3*:​TXK@T_cell
11. PIP2*@Cytosol → PIP3*@Cytosol
12. PDPK1@Cytosol + PIP3*@Cytosol → PDPK1:​PIP3*@Cytosol
13. PIP3*@Cytosol → PIP2*@Cytosol
14. PIP2*@INNATE_IMMUNE_CELL_Cytosol → PIP3*@INNATE_IMMUNE_CELL_Cytosol
15. PDPK1@INNATE_IMMUNE_CELL_Cytosol + PIP3*@INNATE_IMMUNE_CELL_Cytosol → PDPK1:​PIP3*@INNATE_IMMUNE_CELL_Cytosol
16. PIP3*@INNATE_IMMUNE_CELL_Cytosol → PIP2*@INNATE_IMMUNE_CELL_Cytosol
17. PIP2*@Cytosol → PIP3*@Cytosol
18. PDPK1@Cytosol + PIP3*@Cytosol → PDPK1:​PIP3*@Cytosol
19. PIP3*@Cytosol → PIP2*@Cytosol
20. ATG2*@Cytosol → ATG2*:​PIP3*@Autopagosome
21. WIP*@Cytosol → PIP3*:​WIP*@Autopagosome
22. PIP2@Autopagosome → PIP3*@Autopagosome
23. PIP3*@Autopagosome → PIP2@Autopagosome
24. PIP3*@Autopagosome + LC3*@Autopagosome → LC3*:​PIP3*@Autopagosome
25. PIP3*@Autopagosome + DCFP1*@Autopagosome → DCFP1*:​PIP3*@Autopagosome
26. PIP3*@Autopagosome → Autophagosome formation@Autopagosome

1. AKT*|​Thr450_pho@T_cell → AKT*|​Thr308_pho|​Thr450_pho@T_cell
2. VAV1@T_cell → VAV1|​pho|​active@T_cell
3. DAG:​PRKCQ@cSMAC → (DAG:​PRKCQ|​pho)|​active@cSMAC
4. gIFNG@T_cell → rIFNG@T_cell
5. LAT@T_cell + PLCG1@T_cell + GRB2@T_cell + GRAP2@T_cell + GRAP@T_cell → GRAP:​GRAP2:​GRB2:​LAT|​pho:​PLCG1@T_cell
6. GRAP:​GRAP2:​GRB2:​LAT|​pho:​PLCG1@T_cell → GRAP:​GRAP2:​GRB2:​LAT|​pho:​PLCG1|​pho@T_cell
7. AKT*@Cytosol → AKT*|​pho|​active@Cytosol
8. ILK@Cytosol → ILK@Cytosol
9. ca_s1703 + GTP@Cytosol → ca_s1700 + GDP@Cytosol
10. ca_s94 + GTP@Cytosol → ca_s97 + GDP@Cytosol
11. IFNG@INNATE_IMMUNE_CELL_Cytosol → IFNG@default
12. CCL4@INNATE_IMMUNE_CELL_Cytosol → CCL4@default
13. CSF2@INNATE_IMMUNE_CELL_Cytosol → CSF2@default
14. VAV2@INNATE_IMMUNE_CELL_Cytosol → VAV2@INNATE_IMMUNE_CELL_Cytosol
15. VAV3@INNATE_IMMUNE_CELL_Cytosol → VAV3@INNATE_IMMUNE_CELL_Cytosol
16. VAV1@INNATE_IMMUNE_CELL_Cytosol → VAV1|​pho|​active@INNATE_IMMUNE_CELL_Cytosol
17. AKT*@INNATE_IMMUNE_CELL_Cytosol → AKT*|​pho@INNATE_IMMUNE_CELL_Cytosol
18. CYTH1@INNATE_IMMUNE_CELL_Cytosol → CYTH1@INNATE_IMMUNE_CELL_Cytosol
19. AKT*@Cytosol → AKT*|​S473_pho|​T308_pho@Cytosol
20. ATG2*@Cytosol → ATG2*:​PIP3*@Autopagosome
21. WIP*@Cytosol → PIP3*:​WIP*@Autopagosome
22. PIP3*@Autopagosome + DCFP1*@Autopagosome → DCFP1*:​PIP3*@Autopagosome