Complex NGF:TrkA* map
Complex composition:

  1. TrkA* map
  2. NGF map

NGF:​TrkA*@Cytosol

Identifiers
NAME:NGF:TrkA*

References
PMID:22465479
Binding of NGF on TrkA trigger his dimerization
rc_re1710( Regulated Cell Death  map ):
PMID:16939974
neurotrophin binding to Trk receptors results in receptor dimerization and autophosphorylation of their cytoplasmic kinase domains
rc_re1709:( Regulated Cell Death  map ) The lack of NGF suppresses the survival signals controlled by PI3K-Akt, finally leading to a de-repression of the pro-apoptotic Bad; on the other hand, the loss of the survival signals is associated with JNK-mediated transcriptional activation of other pro-apoptotic inducers such as DP5, Bim and Puma.

Modifications:
Participates in complexes:
In compartment: Cytosol
  1. NGF:​TrkA*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. IRS1@Cytosol map + NGF:​TrkA*@Cytosol map + PI3K*@Cytosol map → map IRS1|​pho:​NGF:​PI3K*:​TrkA*@Cytosol map
  2. NGF@Extracellular space map + TrkA*@Cytosol map → map NGF:​TrkA*@Cytosol map
As Catalyser: