Protein NRIF* map

Identifiers
integrin beta 3 binding protein (beta3-endonexin)
HUGO:ITGB3BP HGNC:6157 ENTREZ:23421 UNIPROT:Q13352

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map

References
PMID:15721744
PMID:16252010
NRIF is a substrate for TRAF6-mediated K63 polyubiquitination and that this modification is necessary for its nuclear translocation.

NRIF*@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map

References
rc_re1721( Regulated Cell Death  map ):
PMID:16252010
NRIF undergoes K63 polyubiquitination, associates with TRAF6 and p62, and translocates to the nucleus

NRIF*|​ubi@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map

References
rc_re1721( Regulated Cell Death  map ):
PMID:16252010
NRIF undergoes K63 polyubiquitination, associates with TRAF6 and p62, and translocates to the nucleus

Modifications:
In compartment: Cytosol
  1. NRIF*@Cytosol map
  2. NRIF*|​ubi@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. NGFR-ICD*:​NRIF*:​TRAF6@Cytosol map
  2. NRIF*|​ubi:​SQSTM1:​TRAF6@Cytosol map
  3. NADE*:​NGF:​NGFR:​NRAGE*:​NRIF*@Cytosol map
In compartment: Nucleus
  1. NRIF*|​ubi:​SQSTM1@Nucleus map
Participates in reactions:
As Reactant or Product:
  1. NGF@Extracellular space map + NGFR@Cytosol map + NRAGE*@Cytosol map + NRIF*@Cytosol map + NADE*@Cytosol map → map NADE*:​NGF:​NGFR:​NRAGE*:​NRIF*@Cytosol map
  2. NADE*:​NGF:​NGFR:​NRAGE*:​NRIF*@Cytosol map → map NGFR-ICD*:​NRIF*:​TRAF6@Cytosol map
  3. NRIF*@Cytosol map → map NRIF*|​ubi@Cytosol map
  4. SQSTM1@Cytosol map + NRIF*|​ubi@Cytosol map + TRAF6@Cytosol map → map NRIF*|​ubi:​SQSTM1:​TRAF6@Cytosol map
  5. NRIF*|​ubi:​SQSTM1:​TRAF6@Cytosol map → map NRIF*|​ubi:​SQSTM1@Nucleus map
As Catalyser:
  1. ASK1*@Cytosol map → map ASK1*|​oligomer@Cytosol map
  2. Sphingomyelin@Cytosol map + H2O@Cytosol map → map Ceramide@Cytosol map + Choline Phosphate@Cytosol map
  3. NRAGE*@Cytosol map + XIAP@Cytosol map → map NRAGE*:​XIAP@Cytosol map
  4. AATF@Cytosol map → map degraded
  5. NRAGE*@Cytosol map + GEF*@Cytosol map → map GEF*:​NRAGE*@Cytosol map
  6. NRIF*@Cytosol map → map NRIF*|​ubi@Cytosol map
  7. Caspase3*@Cytosol map → map cleaved~Caspase3*@Cytosol map
  8. Caspase2*@Cytosol map → map cleaved Caspase2*@Cytosol map