Protein TrkA* map

Identifiers
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map

References
PMID:17604717
PMID:22465479
The lack of NGF suppresses the survival signals controlled by PI3K-Akt, finally leading to a de-repression of the pro-apoptotic Bad; on the other hand, the loss of the survival signals is associated with JNK-mediated transcriptional activation of other pro-apoptotic inducers such as DP5, Bim and Puma.

TrkA*@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map

References
rc_re1710( Regulated Cell Death  map ):
PMID:16939974
neurotrophin binding to Trk receptors results in receptor dimerization and autophosphorylation of their cytoplasmic kinase domains

Modifications:
In compartment: Cytosol
  1. TrkA*@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. NGF:​TrkA*@Cytosol map
  2. IRS1|​pho:​NGF:​PI3K*:​TrkA*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. IRS1@Cytosol map + NGF:​TrkA*@Cytosol map + PI3K*@Cytosol map → map IRS1|​pho:​NGF:​PI3K*:​TrkA*@Cytosol map
  2. NGF@Extracellular space map + TrkA*@Cytosol map → map NGF:​TrkA*@Cytosol map
As Catalyser:
  1. PIP2*@Cytosol map → map PIP3*@Cytosol map