Protein NADE* map

Identifiers
nerve growth factor receptor (TNFRSF16) associated protein 1
HUGO:NGFRAP1 HGNC:13388 ENTREZ:27018 UNIPROT:Q00994

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map

References
PMID:15721744
PMID:10764727
NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR.

NADE*@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / DEPENDANCE_RECEPTORS  map

References
rc_re1713:( Regulated Cell Death  map ) PMID:15721744
rc_re1726( Regulated Cell Death  map ):
PMID:11278287
14-3-3?? plays an important role in the modulation of nerve growth factor-dependent p75NTR/NADE-mediated apoptosis by binding zith NADE

Modifications:
In compartment: Cytosol
  1. NADE*@Cytosol map
Participates in complexes:
In compartment: Cytosol
  1. NADE*:​YWHAE@Cytosol map
  2. NADE*:​NGF:​NGFR:​NRAGE*:​NRIF*@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. NGF@Extracellular space map + NGFR@Cytosol map + NRAGE*@Cytosol map + NRIF*@Cytosol map + NADE*@Cytosol map → map NADE*:​NGF:​NGFR:​NRAGE*:​NRIF*@Cytosol map
  2. NADE*:​NGF:​NGFR:​NRAGE*:​NRIF*@Cytosol map → map NGFR-ICD*:​NRIF*:​TRAF6@Cytosol map
  3. NADE*@Cytosol map + YWHAE@Cytosol map → map NADE*:​YWHAE@Cytosol map
As Catalyser:
  1. Sphingomyelin@Cytosol map + H2O@Cytosol map → map Ceramide@Cytosol map + Choline Phosphate@Cytosol map
  2. NRAGE*@Cytosol map + XIAP@Cytosol map → map NRAGE*:​XIAP@Cytosol map
  3. AATF@Cytosol map → map degraded
  4. NRAGE*@Cytosol map + GEF*@Cytosol map → map GEF*:​NRAGE*@Cytosol map
  5. Caspase3*@Cytosol map → map cleaved~Caspase3*@Cytosol map
  6. Caspase2*@Cytosol map → map cleaved Caspase2*@Cytosol map