Identifiers
ELK1, member of ETS oncogene family
HUGO:ELK1 HGNC:3321 ENTREZ:2002 UNIPROT:P19419
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / RCD_GENES
HMC:EVADING_GROWTH_SUPPRESSORS
Survival / MAPK
References
Elk1 is one of the best studied targets of the ERK cascade. Phosphorylation increases the transcriptional activity of Elk1.
PMID:16393692
Maps_Modules
HMC:RESISTING_CELL_DEATH
Regulated Cell Death / APOPTOSIS
Regulated Cell Death / RCD_GENES
References
rc_re141( Regulated Cell Death ):
PMID:17554199
by p53
PMID:17656095
PMID:17540599
PMID:17554337
PMID:19696787
in TIG3 TERT/??B-RAF:ER, by ELK1 (siRNA ELK1 and MIR34A PCR; ChIP)
in HEK293 by ELK1, gene reporter
References
su_mpk1_mpk1_re91( Survival ):
The rapid and efficient phosphorylation of Elk1 by ERKs is enabled by a direct interaction between the two proteins.
ELK1 is a nuclear P38 target.
ELK1 is a nuclear JNK target.
PMID:16393692 PMID:20506250 PMID:11274345
su_mpk1_mpk1_re212( Survival ):
ELK1 induces c-fos expression.
PMID:11274345