Reaction known_transition_omitted em_emtc_emtc_re1186 map

TWIST1@Nucleus map → TWIST1|​S68_pho@Nucleus map

Reaction regulators:
Unknown_catalysis
  1. p38*@Nucleus map
  2. ERK1_2*@Nucleus map
  3. JNK*@Nucleus map


References
PMID:21502402
Phosphorylation of serine 68 of Twist1 stabilizes Twist1 protein and promotes breast cancer cell invasiveness.
Twist1 can be phosphorylated in vitro at Serin 68 by MAPKs (p38MAPKs, JNKs, ERK1/2)
This phosphorylation is required for Twist1 protein stability.
pSer 68 stabilizes Twist1 by protecting Twist1 from ubiquitination
Ser 68 phosphorylation is required for Twist1- promoted EMT and breast cancer cell invasion