RNA SERPINF1 map

Identifiers
HUGO:SERPINF1

Maps_Modules
HMC:TUMOR_PROMOTING_INFLAMMATION
HMC:ACTIVATING_INVASION_AND_METASTASIS
 Cancer Associated Fibroblasts  map  / CAF_INHIBITION_ANTITUMOR  map

References
PMID:26921338
(PEDF, SERPINF1) normal dermal fibroblasts expressing high PEDF levels attenuated melanoma growth and angiogenesis in vivo, whereas PEDF-depleted fibroblasts exerted tumor-promoting effects.
melanoma cells produced PDGF-BB and TGF??, which blocked PEDF production in fibroblasts. Notably, cancer-associated fibroblasts (CAF) isolated from patient-derived tumors expressed markedly low levels of PEDF. Treatment of patient CAF and TGF??-treated normal fibroblasts with exogenous PEDF decreased the expression of CAF markers and restored PEDF expression. Finally, expression profiling of PEDF-depleted fibroblasts revealed induction of IL8, SERPINB2, hyaluronan synthase-2, and other genes associated with tumor promotion and metastasis.
PEDF treatment strongly elevated cytoplasmic PEDF levels in the activated fibroblasts, suggesting a positive feedback loop.

Modifications:
In compartment: Cytosol
  1. rSERPINF1@Cytosol map
Participates in complexes:
    Participates in reactions:
    As Reactant or Product:
    1. gSERPINF1@Cytosol map → map rSERPINF1@Cytosol map
    2. rSERPINF1@Cytosol map → map SERPINF1@Cytosol map
    As Catalyser: