Protein ITCH map

Identifiers
itchy E3 ubiquitin protein ligase homolog (mouse)
HUGO:ITCH, HGNC:13890, ENTREZ:83737, UNIPROT:Q96J02
itchy E3 ubiquitin protein ligase
Itchy
HUGO:ITCH HGNC:13890 ENTREZ:83737 UNIPROT:Q96J02 GENECARDS:ITCH REACTOME:93459 KEGG:83737 ATLASONC:GC_ITCH WIKI:ITCH

Maps_Modules
HMC:SUSTAINING_PROLIFERATIVE_SIGNALLING
 Cell Cycle DNA Repair  map  / G2_M_CHECKPOINT  map
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / NECROPTOSIS  map
 Regulated Cell Death  map  / TNF_RESPONSE  map
HMC:EVADING_GROWTH_SUPPRESSORS
 Survival  map  / HEDGEHOG  map

References
PMID:11318614, PMID:18628966, PMID:10940313, PMID:16861923, PMID:21107885, PMID:21383157
PMID:16469705
PMID:18552861
E3 ubiquitin protein ligase homologue

ITCH@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / NECROPTOSIS  map
 Regulated Cell Death  map  / TNF_RESPONSE  map

References
rc_re1541( Regulated Cell Death  map ):
PMID:16469705
The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.

ITCH|​pho@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / NECROPTOSIS  map
 Regulated Cell Death  map  / TNF_RESPONSE  map

References
rc_re1541( Regulated Cell Death  map ):
PMID:16469705
The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover.
rc_re1542( Regulated Cell Death  map ):
JNK antagonizes NF-kappaB during TNFalpha signaling by promoting the proteasomal elimination of c-FLIP(L).
PMID:26972597
FADD regulates NF-?B activation and promotes ubiquitination of cFLIPL to induce

ITCH|​unk@Cytosol

Maps_Modules
HMC:RESISTING_CELL_DEATH
 Regulated Cell Death  map  / ANTIOXIDANT_RESPONSE  map
 Regulated Cell Death  map  / STARVATION_AUTOPHAGY  map
 Regulated Cell Death  map  / DEATH_RECEPTOR_PATHWAYS  map
 Regulated Cell Death  map  / NECROPTOSIS  map
 Regulated Cell Death  map  / TNF_RESPONSE  map

References
rc_re1135( Regulated Cell Death  map ):
PMID:20068034
in H1299, ITCH downregulates the expression of TXNIP (siRNA against ITCH, ITCH ectopic expression), ITCH interacts with TXNIP and promotes its ubiquitinylation
in vitro, in H1299, reconstitution of the ubiquitin-ligase system

Modifications:
In compartment: Cytosol
  1. ITCH@Cytosol map
  2. ITCH|​pho@Cytosol map
  3. ITCH|​unk@Cytosol map
In compartment: Nucleus
  1. ITCH@Nucleus map
Participates in complexes:
In compartment: Cytosol
  1. ITCH:​NUMB@Cytosol map
Participates in reactions:
As Reactant or Product:
  1. ITCH@Cytosol map → map ITCH|​unk@Cytosol map
  2. ITCH|​pho@Cytosol map → map ITCH|​unk@Cytosol map
  3. ITCH@Cytosol map → map ITCH|​pho@Cytosol map
  4. ITCH@Cytosol map → map ITCH|​unk@Cytosol map
  5. ITCH@Cytosol map → map ITCH|​pho@Cytosol map
  6. ITCH@Cytosol map + NUMB@Cytosol map → map ITCH:​NUMB@Cytosol map
As Catalyser:
  1. p73*@Nucleus map → map YAP1|​pho:​p73*|​Y99_pho@Nucleus map
  2. TXNIP@Cytosol map → map TXNIP|​ubi@Cytosol map
  3. CFLAR@Cytosol map → map CFLAR|​pho@Cytosol map
  4. RIPK1|​K377_ubi@TNFRSF1 Receptor Complex map → map RIPK1@TNFRSF1 Receptor Complex map
  5. RIPK1@TNFRSF1 Receptor Complex map → map RIPK1|​ubi@TNFRSF1 Receptor Complex map
  6. CFLAR@Cytosol map → map CFLAR|​ubi@Cytosol map
  7. GLI1@Cytosol map → map GLI1|​ubi|​ubi@Cytosol map