Reaction state_transition rc_re1316 map

JNK*@Cytosol map → JNK*|​Y185_pho@Cytosol map

Reaction regulators:
Catalysis
  1. MAP2K7|​pho@Cytosol map
Inhibition
  1. ROS Production@Cytosol map


References
PMID:12624093
in mouse embryonic cells, with targeted disruption of either MAP2K4 or MAP2K7, the phosphorylation pattern of JNK reveals sequential phosphorylation by these MAP2KsPMID:19037093
under glucose deprivation condition, ROS are generated leading to an inactivation of JNK activity