Protein PXN map

Identifiers
HUGO:PXN
paxillin
HUGO:PXN HGNC:9718 ENTREZ:5829 UNIPROT:P49023

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Adaptive Immune Response  map  / TCR_SIGNALING  map
HMC:ACTIVATING_INVASION_AND_METASTASIS
 EMT Senescence  map  / EMT_REGULATORS  map
 EMT Senescence  map  / CELL_MATRIX_ADHESIONS  map

References
PMID:22043013 PMID:29021139
PMID:16000375
Src and FAK kinases cooperate to phosphorylate paxillin, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.
Phosphorylated paxillin binding to Crk is implicated in Rac activation and stimulation of cell motility
PMID:15308668
CRK bound to DOCK1 (so-called DOCK180) forms complex with phosphorylated paxillin.
The complex is necessary for collagen-dependent cell migration, mainly through Rac1 activation.
CASCADE:NKG2D
PMID:18287025
JNK induces assosiation of Paxilin with MTOC resulted in polarization of the MTOC and cytolytic granules, and finally exocytosis of cytolytic proteins downstream of NKG2D.

PXN|​pho|​active@Cytosol

References
mo_re101:( motility  map ) PMID:23418787 PMID:17409395

PXN@Cytosol

References
mo_re101:( motility  map ) PMID:23418787 PMID:17409395

PXN|​pho@Cytosol

References
em_emtc_emtc_re980( EMT Senescence  map ):
PMID:16919435
PMID:16000375
Upon autophosphorylation of FAK, a signaling complex of FAK, CSK binds to and can phosphorylate various adaptor proteins such as p130Cas and paxillin.
Src and FAK kinases cooperate to phosphorylate paxillin, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.
Phosphorylated paxillin binding to Crk is implicated in Rac activation and stimulation of cell motility
em_emtc_emtc_re981( EMT Senescence  map ):
PMID:15308668
CRK bound to DOCK1 (so-called DOCK180) forms complex with phosphorylated paxillin.
The complex is necessary for collagen-dependent cell migration, mainly through Rac1 activation.

Modifications:
In compartment: Cytosol
  1. PXN@Cytosol map
  2. PXN|​pho@Cytosol map
  3. PXN|​pho|​active@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PXN@INNATE_IMMUNE_CELL_Cytosol map
In compartment: T_cell
  1. PXN@T_cell map
  2. PXN|​pho@T_cell map
Participates in complexes:
In compartment: Cytosol
  1. DOCK1:​PXN|​pho@Cytosol map
  2. FAK*|​pho:​PXN|​pho:​Vinculin*:​others*@Cytosol map
  3. BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map
  4. Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map
  5. Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​ZYX:​c-SRC*@Cytosol map
  6. ARP2_3*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map
In compartment: INNATE_IMMUNE_CELL_Cytosol
  1. PXN:​TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@INNATE_IMMUNE_CELL_Cytosol map
In compartment: T_cell
  1. PXN:​TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@T_cell map
Participates in reactions:
As Reactant or Product:
  1. TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@T_cell map + PXN|​pho@T_cell map → map PXN:​TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@T_cell map
  2. PXN:​TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@T_cell map → map Centrosome polarization@T_cell map
  3. PXN@T_cell map → map PXN|​pho@T_cell map
  4. PXN@Cytosol map → map PXN|​pho@Cytosol map
  5. PXN|​pho@Cytosol map + CRK@Cytosol map + DOCK1@Cytosol map → map DOCK1:​PXN|​pho@Cytosol map
  6. DOCK1:​PXN|​pho@Cytosol map → map Membrane spreading@Cytosol map
  7. FAK1*|​Y_pho|​pho:​c-SRC*@Cytosol map + BCAR1@Cytosol map + Talin*@Cytosol map + PXN|​pho@Cytosol map + Vinculin*@Cytosol map → map BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map
  8. BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map + Actinin*@Cytosol map + Actin cytoskeletal*@Cytosol map → map Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map
  9. Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map + ZYX@Cytosol map → map Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​ZYX:​c-SRC*@Cytosol map
  10. ARP2_3*@Cytosol map + Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map → map ARP2_3*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map
  11. ARP2_3*:​Actinin*:​BCAR1:​FAK1*|​Y_pho|​pho:​PXN|​pho:​Talin*:​c-SRC*@Cytosol map → map Actin polymerization@Nucleus map
  12. TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@INNATE_IMMUNE_CELL_Cytosol map + PXN@INNATE_IMMUNE_CELL_Cytosol map → map PXN:​TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@INNATE_IMMUNE_CELL_Cytosol map
  13. PXN:​TUBGCP2:​TUBGCP3:​TUBGCP4:​TUBGCP5:​TUBGCP6:​Tubulin-_alpha_*:​Tubulin-_beta_*:​Tubulin-_gamma_*@INNATE_IMMUNE_CELL_Cytosol map → map MTOC_polarization@INNATE_IMMUNE_CELL_Cytosol map
  14. rPXN@Nucleus map → map PXN@Cytosol map
  15. PXN|​pho|​active@Cytosol map → map PXN@Cytosol map
  16. FAK*|​pho:​PXN|​pho:​Vinculin*:​others*@Cytosol map → map Cell-matrix adhesions@default map
  17. PXN@Cytosol map → map PXN@Cytosol map
  18. others*@Cytosol map + Vinculin*@Cytosol map + PXN|​pho|​active@Cytosol map + FAK*|​pho|​active@Cytosol map → map FAK*|​pho:​PXN|​pho:​Vinculin*:​others*@Cytosol map
  19. PXN@Cytosol map → map PXN|​pho|​active@Cytosol map
As Catalyser:
  1. FAK1*|​emp@Cytosol map → map FAK1*|​pho@Cytosol map