Identifiers
HUGO:MST1
macrophage stimulating 1 (hepatocyte growth factor-like)
D3F15S2 DNF15S2 HGFL
HUGO:MST1 HGNC:7380 ENTREZ:4485 UNIPROT:P26927HUGO:MST1

Maps_Modules
HMC:AVOIDING_IMMUNE_DESTRUCTION
 Innate Immunity   / IMMUNOSTIMULATORY_CORE_PATHWAYS 

References
 NATURAL_KILLER 
CASCADE:NKG2D
PMID:19454690, PMID:16892067
Ligation of either FcR or NKG2D increased phosphorylation of MST1
in NK cells. Probably via RAPL.
NKG2D signaling increases integrin-dependent NK cell adgesion,
promably via MST1 which can upregulate LFA-1/ICAM1 adhesion
PMID:23792360

References
su_mpk1_mpk1_re261( Survival  ):
JNK phosphorylates MST1 at serine 82 which leads to the enhancement of MST1 activation. The activation of MST1 phosphorylates FOXO3 at serine 207 and promotes cell death.
PMID:20028971

References
su_mpk1_mpk1_re261( Survival  ):
JNK phosphorylates MST1 at serine 82 which leads to the enhancement of MST1 activation. The activation of MST1 phosphorylates FOXO3 at serine 207 and promotes cell death.
PMID:20028971
su_mpk1_mpk1_re262( Survival  ):
Phosphorylation of FOXO3 by Akt creates a binding site for the 14-3-3 family of proteins. The complex of FOXO3 and 14-3-3 is retained in the cytosol blocking transcription of genes normally stimulated by FOXO3.
PMID:20028971 PMID:12040186

1. MST1@INNATE_IMMUNE_CELL_Cytosol

1. MST1@Membrane

1. MST1@Nucleus
2. MST1|​pho@Nucleus

1. MST1|​pho:​RASSF5@INNATE_IMMUNE_CELL_Cytosol

1. MST1:​MST1R|​pho@Membrane

1. MST1|​pho:​RASSF5@INNATE_IMMUNE_CELL_Cytosol → Conjugate_formation@INNATE_IMMUNE_CELL_Membrane
2. RASSF5@INNATE_IMMUNE_CELL_Cytosol + MST1@INNATE_IMMUNE_CELL_Cytosol → MST1|​pho:​RASSF5@INNATE_IMMUNE_CELL_Cytosol
3. MST1@Membrane + MST1R@Membrane → MST1:​MST1R|​pho@Membrane
4. MST1:​MST1R|​pho@Membrane → PI3K_PATHWAY@Membrane
5. MST1:​MST1R|​pho@Membrane → MAPK_PATHWAYS@Membrane
6. MST1@Nucleus → MST1|​pho@Nucleus

1. FOXO3@Cytoplasm → FOXO3|​pho@Nucleus